Results 61 to 70 of about 388,124 (318)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Bearing Surface Pressure Distribution of Nut with Cone-form Bearing Surface
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2008 Recently, wheel separation accidents in such vehicles as trucks, buses and passenger cars have drawn a social concern. Explications of their causes and adequate practices of countermeasures for them have been urgently required. In relation to this issue,
Manabu OKADA, Shinji KASEI
doaj +1 more source
CONSUMER PERCEIVED RISK IN CAR PURCHASE [PDF]
ICTACT Journal on Management Studies, 2018 This paper presents a study on consumer perceived risk towards their purchase decision to buy automobiles in India, having knowledge of various aspects of consumer buying process can help companies significantly when developing strategies to increase ...
K Rajendran, J Jayakrishnan
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
, 1908 This folder contains business records of Standard Automobile Company of Wichita, Kansas, dated between November 28, 1908 and December 20, 1909. There are canceled checks, part receipts, and replies to orders.
Standard Automobile Company of Wichita, Kansas
core +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Application and Development of Automatic Speech Recognition in Vehicle Field
Kongzhi Yu Xinxi Jishu, 2019 As a key technology of artificial intelligence, speech recognition has enjoyed widespread popularity, and the appearance of deep learning makes it possible to commercialize speech recognition.
LIU Yue, LIN Jun, YOU Jun
doaj
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source