Results 151 to 160 of about 2,084 (192)

The Documentation of Injuries Caused by Traffic Accidents. [PDF]

Dtsch Arztebl Int
Hartung B, Schäuble A, Peldschus S, Schüssler M, Meyer HL.   +4 more
europepmc   +1 more source

Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery

Advanced Science, EarlyView.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source

Pilot Study on Gaze Characteristics of Older Drivers While Watching Driving Movies. [PDF]

Geriatrics (Basel)
Kawabata K, Nakajima Y, Fujita K, Sato M, Hayashi K, Kobayashi Y.   +5 more
europepmc   +1 more source

POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 Lactylation

Advanced Science, EarlyView.
Schematic diagram of our study showing that highly expressed POU2F1 in colorectal cancer (CRC) can directly accelerate the cytosolic lactate export to decrease PPP1R11 lactylation at K59, thereby attenuating the E3 ligase enzyme activity and protein stability of PPP1R11, which inhibits the ubiquitination of MDR2 at K413 and K538 but increases the ...
Longzheng Xia, Jinguan Lin, Xianjie Jiang, Linda Oyang, Shiming Tan, Zongyao Ren, Qiu Peng, Qianjin Liao, Yujuan Zhou   +8 more
wiley   +1 more source

Common driving behaviors in older adults with dementia: Insights from a systematic literature review. [PDF]

Alzheimers Dement
Hettiarachchige RO, Rapoport MJ, Naglie G, Vingilis E, Seeley J, Alizadeh S, Bayat S.   +6 more
europepmc   +1 more source

One‐Step Glycoengineering of NK Cells With High‐Affinity Siglec Ligands for Cancer Immunotherapy

Advanced Science, EarlyView.
This study develops an engineered NmCSS enzyme with improved activity for bulky group modified sialic acids, enabling efficient synthesis of structurally diverse sialoside analogs in a single step. Glycan microarray screening identified Siglec high‐affinity ligands, which were incorporated onto natural killer (NK) cells via a one‐pot enzymatic system ...
Shuai Hu, Ben Huang, Lingyan Wang, Qiang Guo, Cuiping Jiang, Ruicheng Qi, Shuyao Wang, Lin‐Tai Da, Wenjie Peng   +8 more
wiley   +1 more source

An Open-Road Driving Performance Task to Examine Long-Term Medical Marijuana Use and Prescription Opioid Positivity Among Adults Aged 50 Years and Older: Protocol for an Observational Trial.

JMIR Res Protoc
Ennis N, Classen S.
europepmc   +1 more source

Cultural influences on road safety in Vanuatu: masculinity norms and their impact on dangerous driving behaviors. [PDF]

Front Public Health
Fanai S, Okyere E, Marfoh K.
europepmc   +1 more source

Assessing and predicting crash dynamics with and without road safety measures on the Dejen to Bahir Dar highway in Ethiopia. [PDF]

Sci Rep
Geremew G.
europepmc   +1 more source