Results 181 to 190 of about 882,956 (246)

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

Machine Learning of Temperature‐Dependent Chemical Kinetics Using Parallel Droplet Microreactors

Advanced Science, EarlyView.
An integrated droplet microfluidics and machine learning framework enables high‐throughput characterization of temperature‐dependent reaction kinetics. Time‐resolved measurements from thousands of droplets train Neural ODE models that accurately predict nonlinear reaction dynamics across diverse thermal environments, bridging large‐scale ...
Mamoru Saita, Yutaka Hori
wiley   +1 more source

The Landscape of Long Non‐Coding RNAs Provides Insights Into the Domestication and Improvement of Pear Fruit

Advanced Science, EarlyView.
This study reveals that long non‐coding RNAs represent important regulatory components underlying pear domestication and improvement. Integrative multi‐omics analyses identify selected lncRNAs associated with fruit traits, while functional validation uncovers a lignin‐related lncRNA, lncRNA‐pys, that promotes lignin accumulation.
Bobo Song, Peilin Han, Jiaming Li, Xiaolong Li, Xiang Zhang, Jing Fan, Dongliang Liu, Jianfa Cai, Lingchao Zhang, Jun Wu   +9 more
wiley   +1 more source

Safe Driving: Human Limitations in Automobile Driving

Journal of the American Medical Association, 1937
openaire   +2 more sources

Reversible Exfoliation‐Aggregation Dynamics in Ionic COFs for Tunable Interfacial Catalysis

Advanced Science, EarlyView.
A unique ionic covalent organic framework (I‐4) exhibits unprecedented concentration‐dependent dynamic behavior in water, undergoing reversible transitions between aggregation and exfoliation. This enables fully controllable, bidirectional modulation of its particle size and surface micro‐environment.
Jilu Yang, Xiaofei Zhang, Yue Li, Yuping Cao, Zhaowei Jia, Bo Li, Haitao Feng, Xiaoqiang Cui, Wenwu Qin   +8 more
wiley   +1 more source

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Automobile driving in Huntington's disease

Movement Disorders, 1995
AbstractWe assessed the influence of the neurological and cognitive impairments of Huntington's disease (HD) on automobile driving. In a group of 73 HD outpatients, 53 (72%) continued to drive after illness onset. Those no longer driving had more severe symptoms than those still driving.
Jason Brandt, G W Rebok, F W Bylsma
exaly   +3 more sources

On the Driving of Automobiles by Older People

Journal of Gerontology, 1964
A review of the evidence pertaining to the problem of the ageing driver showed that in 1940, 5.9% of the population of licensed drivers was over 60 years of age; by 1960 this proportion had increased to 11.4%. In terms of accidents per licensee, those drivers below the age of 24 and those over the age of 60 years have worse records than those in the ...
R A, MCFARLAND, G S, TUNE, A T, WELFORD
openaire   +2 more sources

Marihuana and Automobile Driving

JAMA: The Journal of the American Medical Association, 1972
To the Editor.— The report in INTERNATIONAL COMMENTS (220:139, 1972) pertaining to the adverse influence of marihuana on driving exemplifies a problem which has been minimized in the discussions over legalization of the drug. In the above report, emanating from West Germany, test subjects had marked deterioration in driving ability after having smoked
openaire   +2 more sources

Mathematical biology of automobile driving

The Bulletin of Mathematical Biophysics, 1967
Continuing a previous study (Bull. Math. Biophysics, 28, 645–654, 1966), the biophysical mechanism of a corrective turn is investigated for the case where the stimulus for the corrective turn is produced not only by the perception of the nearness of an edge of the lane, but also by the rate of approach of the car towards the edge.
openaire   +5 more sources

Automobile driving as psychophysical discrimination

The Bulletin of Mathematical Biophysics, 1962
The driver tries to keep the car in the center of the lane. If the car is too near the left edge, this causes the driver to make a “corrective” right turn. If the car is near the right edge, a “corrective” left turn is made. Therefore, a quantity which decreases with increasing distance ΔL from the left edge may be considered as a stimulusSR producing ...
openaire   +3 more sources