Research on the Accelerated Fatigue Experiment Method of the Crankshaft Based on a Modified Particle Filtering Algorithm and the Fatigue Crack Growth Property. [PDF]
Fu J +5 more
europepmc +1 more source
A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu +17 more
wiley +1 more source
NOx/N<sub>2</sub>O Formation and Coordinated Urea-SCR Control in an Ultra-Lean Hydrogen-Fueled Automotive SI Engine: Engine Mapping and WLTC Strategy Evaluation. [PDF]
Jiang J, Yang J, Cheng Y.
europepmc +1 more source
A digitized image of a pamphlet for Instructions for O.S FP Series Engines (Max- 20FP, 25FP, 35FP, and 40FP)
O.S. Engines
core
Geometry‐Encoded Actuation as a Structural Interaction Layer in Origami Robots
We present geometry‐encoded actuation (GEA), a design framework that integrates multistable origami with liquid crystal elastomer actuators to encode environmental interactions into autonomous structural responses. GEA enables programmable shape transformation without continuous sensing or complex control, achieving robust adaptive manipulation and ...
Jianshu Zhou +8 more
wiley +1 more source
Molecular hydrogen: a potential guardian against environmental radiation damage. [PDF]
Ichikawa Y, Sato B, Takefuji Y, Satoh F.
europepmc +1 more source
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie +10 more
wiley +1 more source
Environment-Dependent Wear Mechanisms of Diamond-Like Carbon/Fe Interface under H<sub>2</sub>O and HNO<sub>3</sub> Aqueous Environments: A Reactive Molecular Dynamics Study. [PDF]
Yokoi M +5 more
europepmc +1 more source
Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng +16 more
wiley +1 more source

