Results 201 to 210 of about 358,824 (288)

Macrophage Trogocytosis of Tumor Cells Drives the Immunosuppression of Tumor Microenvironment

open access: yesAdvanced Science, EarlyView.
Trogocytosis efficiency varies significantly among different tumor cells and is inversely related to their cortical stiffness; this efficiency dictates the extent of immunosuppression via upregulation of CXCL5 and Arg‐1, ultimately driving CD8+T cell exhaustion and tumor escape.
Chao Liang   +9 more
wiley   +1 more source

Machine learning predictions for enhancing engine performance and emission using aluminum oxide nano additives in castor biodiesel. [PDF]

open access: yesSci Rep
Nachippan M   +6 more
europepmc   +1 more source

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

open access: yesAdvanced Science, EarlyView.
AMT‐676 is a novel antibody‐drug conjugate targeting CDH17, an adhesion molecule uniquely exposed on gastrointestinal tumor surfaces. Engineered with an optimized exatecan payload, it demonstrates profound tumor regression and a robust bystander effect across diverse preclinical models.
Ying‐nan Wang   +21 more
wiley   +1 more source

Epigenetic Reactivation of TNFRSF19 Suppresses Mitophagy and Sensitizes Triple‐Negative Breast Cancer to Doxorubicin

open access: yesAdvanced Science, EarlyView.
TNFRSF19 is an epigenetically silenced regulator of mitophagy in triple‐negative breast cancer. TNFRSF19 deficiency activates the TGFBR1–SMAD3–PINK1 axis to promote mitophagy and confer doxorubicin resistance, whereas decitabine‐mediated restoration of TNFRSF19 suppresses mitophagy and enhances doxorubicin sensitivity, revealing a targetable epigenetic–
Shiyang Liu   +7 more
wiley   +1 more source

MXene‐Based Room‐Temperature NO2 Gas Sensors: A Meta‐Analysis

open access: yesAdvanced Science, EarlyView.
This study presents the first comprehensive meta‐analysis of MXene‐based NO2 sensors, decoding 32 study characteristics across 61 peer‐reviewed studies. By isolating materials chemistry as the primary performance driver over device‐level parameters, the authors establish a methodological blueprint and a predictive structure–function map to accelerate ...
Alexander Khort   +3 more
wiley   +1 more source

Controlled Lattice Distortion and Lattice‐Strain‐Engineered CoCuIr Alloy toward Preferential Chlorine Tolerant Direct Seawater Electrolysis

open access: yesAdvanced Science, EarlyView.
A lattice‐strain‐engineered Co0.28Cu0.67Ir0.05 trimetallic alloy nanoparticle electrocatalyst is rationally designed for efficient alkaline seawater electrolysis. Larger Ir atoms in the CoCu lattice modulate the local coordination environment, generating compressive lattice strain and highly active catalytic sites.
Ankur Kumar   +5 more
wiley   +1 more source

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