Results 131 to 140 of about 3,223,371 (261)

Klotho‐Derived Peptide 1 Protects against Acute Kidney Injury by Directly Targeting Mitochondrial ATAD3A

open access: yesAdvanced Science, EarlyView.
This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang   +6 more
wiley   +1 more source

Single‐Dose TACE‐Like Injection of Sustained‐Release Panobinostat/IL‐12 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models

open access: yesAdvanced Science, EarlyView.
A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu   +7 more
wiley   +1 more source

"Automobiles: Strategy-based Lean Production System" [PDF]

open access: yes
The present situations and future prospects of the Japanese automobile industry are discussed. Selected topics in this paper include the following: analyses of the basic product-industry characteristics of the automobile (e.g., product architecture); the
Takahiro Fujimoto, Akira Tateishi
core  

A Drug‐Gated, Modular STAb‐T Immunotherapy With External Control

open access: yesAdvanced Science, EarlyView.
Engineered STAb‐TON cells act as programmable living factories that continuously secrete inactive antibody modules, which assemble extracellularly into a functional T cell engager only upon small‐molecule administration. This externally controlled platform enables reversible, on‐demand regulation of antitumor immunity, establishing a new paradigm for ...
Susana Luengo‐Arias   +23 more
wiley   +1 more source

Factories of Apperson Brothers Automobile Co. Kokomo, Indiana

open access: yes, 1910
In the early years of the automotive industry, Apperson Brothers Automobile Company became a prominent fixture in Kokomo from 1902 to 1926. This aerial illustration of the plant, as depicted in a 1915 promotional catalog, shows Apperson during its peak ...
Apperson Brothers Automobile Company
core  

China's Low‐Carbon Energy Transition Over the Past Two Decades: Experiences and Implications

open access: yesAdvanced Science, EarlyView.
China's low‐carbon energy transition features a brief decline and subsequent rebound in coal consumption, alongside the rapid expansion of renewable energy. This study develops a stage‐based analytical framework to explain this evolution from the perspectives of economic development, energy security, and environmental sustainability, revealing how ...
Yu Liu   +3 more
wiley   +1 more source

The Keiretsu Fable - Where does the Truth Lie? [PDF]

open access: yes
The success of the Japanese automobile industry has mystified Western scholars for many decades. In the early post-war years, the industry did not receive any blessings from the Bank of Japan.
Anderson, Evelyn
core  

OsCPK12‐OsATPD1 Module Regulates Photosynthetic Acclimation to Light Stress in Rice

open access: yesAdvanced Science, EarlyView.
OsCPK12 interacts and phosphorylates OsAtpD1 at Ser8 in its transit peptide. This phosphorylation promote its chloroplast translocation, thereby maintaining ATP synthase activity and proton gradient (ΔpH) homeostasis and regulating photosynthetic acclimation, photoprotection, and repair under light stress.
Beifang Wang   +17 more
wiley   +1 more source

Crisis in the European Automobile Industry: An “Organizational Adaptation” Perspective [PDF]

open access: yes
The paper explores the determinants of corporate crisis through an «organizational adaptation» perspective. In this regard, a research framework recently developed by scholars is at first shown.
Gianpaolo Abatecola
core  

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