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Sheep Horn Development Revealed by Multi‐Tissue and Cross‐Species Transcriptomic Analysis

open access: yesAnimal Research and One Health, EarlyView.
Multi‐tissue and cross‐species transcriptomics with allele‐specific expression show sheep horns are a composite organ integrating epidermal and osteogenic programs. Conserved horn gene modules and cis‐regulatory variation fine‐tune expression networks underlying horn development and size (small scurs vs. large spiral horns).
Hao Li   +10 more
wiley   +1 more source

Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing

open access: yesAnimal Research and One Health, EarlyView.
Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley   +1 more source

Autonomic nervous system maturation in preterm neonates: Correlation with gestational and postmenstrual age (ProMote). [PDF]

open access: yesPLoS One
Kokkinaki T   +10 more
europepmc   +1 more source

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