Results 141 to 150 of about 143,175 (352)
Advanced Science, EarlyView.This study identifies CARD9 as a key mediator linking sympathetic β2‐adrenergic receptor signaling to macrophage creatine metabolism, inflammatory polarization, and neuronal integrity. Loss of β2‐AR‐PKA‐CREB1‐CARD9 signaling in macrophages reduces creatine uptake, promotes pro‐inflammatory macrophage activation, and drives sympathetic axon ferroptosis.
Huimin Yuan +12 more
wiley +1 more source
BiomedicinesPurpose: The prevalence and phenotype of capillaroscopic abnormalities in patients with autonomic nervous system dysfunction have not yet been investigated. Multiorgan involvement in dysautonomia entails abnormal vasoreactivity.
Sehreen Mumtaz +5 more
doaj +1 more source
Arrhythmias After Tetralogy of Fallot Repair [PDF]
, 2005 Tetralogy of Fallot is the most common cyanotic congenital heart disease, with a good outcome after total surgical correction. In spite of a low perioperative mortality and a good quality of life, late sudden death remains a significant clinical problem,
Daliento, Luciano +1 more
core +1 more source
Microvascular Health as a Key Determinant of Organismal Aging
Advanced Science, EarlyView.This review spotlights the emerging field of vascular aging, providing a comprehensive and critical overview of the molecular processes and clinical manifestations of vascular dysfunction during aging. By combining basic angioscience concepts with a critical analysis of innovative pre‐clinical aging models and lifestyle interventions, it offers a ...
Mattia Cenciarini +4 more
wiley +1 more source
Original paper
Heart rate variability in patients with recurrent syncope
Archives of Medical Science, 2006 Introduction: The autonomic nervous system participates in the pathophysiology of vasovagal syncope. The disturbances in the autonomic nervous system can be measured by heart rate variability (HRV).
Jan Henryk Goch, Małgorzata Lelonek
doaj
Epicardial fat and liver disease; the contribution of cardio autonomic nervous system function [PDF]
, 2015 Şeref Ulucan +2 more
openalex +1 more source
Advanced Science, EarlyView.Integrated omics analysis of matched primary and liver metastatic NPC tumors reveals a unique NOTCH1+ CSC subpopulation exhibiting enhanced stemness properties and tumorigenic capacity. With in vitro and in vivo assays, exosomal transfer of tumor‐derived FTO from NOTCH1+ cells to the endothelium promotes vascular permeability and metastatic potential ...
Chun Wu +23 more
wiley +1 more source
Stress‐Induced Activation of Prolactin‐NR4A1‐Midkine Axis Exacerbates Skin Inflammation
Advanced Science, EarlyView.Chronic psychological stress activates prolactin signaling to reprogram dermal fibroblasts into APCDD1+ inflammatory effectors via NR4A1, driving midkine secretion. This paracrine hub amplifies keratinocyte proliferation and immune recruitment, thus exacerbating skin inflammation.
Zhiguo Li +18 more
wiley +1 more source