Results 41 to 50 of about 3,517,486 (301)

El personal directivo en las leyes autonómicas de desarrollo del ebep

Revista Vasca de Administración Pública, 2011
The Basic Statute for Civil Servants (EBEP in Spanish) came into force more than four years ago, and also its article 13. This article 13 made a call to (state and regional) executives to establish a regime for the managerial staff, if they so wished ...
Luis F. Maeso Seco
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

El sistema español de jerarquía lingüística. Desarrollo autonómico del artículo 3 de la Constitución: lengua del Estado, lenguas cooficiales, otras lenguas españolas y modalidades lingüísticas. Teoría y praxis. // The Spanish system of language hierarchy. Autonomic development of article 3 of the Constitution: State language, co-official languages, other Spanish languages and language modalities. Theory and praxis.

Revista de Derecho Político, 2017
Resumen: Este trabajo pretende dar una visión general del reconocimiento de la diversidad lingüística española que se deriva de la Constitución. Nos referimos exclusivamente a las lenguas autóctonas históricamente habladas en España; teniendo en cuenta ...
Vicenta Tasa Fuster
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Los Órganos de control externo (OCEX): una aproximación desde la perspectiva de las Relaciones Intergubernamentales

Revista Vasca de Administración Pública, 2017
Intergovernmental relations in Spain have been characterized by mistrust and a lack of collaboration among political actors. In this context of intergovernmental controversy, this article presents a case of success related to several good practices ...
María Ángeles Abellán López, Bernabé Aldeguer Cerdá   +1 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Open Data to Promote the Economic and Commercial Development of the Housing Sector: The Case of Spain

Urban Science
Data is the starting point for generating information and knowledge in the decision-making process. Open data, which is information disclosed free of charge through open licenses and reusable formats, has great potential for value creation.
Ricardo Curto-Rodríguez, Rafael Marcos-Sánchez, Alicia Zaragoza-Benzal, Daniel Ferrández   +3 more
doaj   +1 more source

El voto preferencial en las Comunidades Autónomas: propuestas y condicionantes jurídicos [PDF]

Revista d'Estudis Autonòmics i Federals, 2019
In recent years, mechanisms have been activated in order to carry out political reforms in the Autonomous Communities, due to the greater fragmentation that exists in regional parliaments and the presence of political parties that support institutional ...
Carlos Fernández-Esquer, Javier Sierra-Rodríguez   +1 more
doaj  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source