Results 41 to 50 of about 35,867 (247)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

The constitutional guarantee of the provision of local Social Services in Spain: a comparative regional study

open access: yesRevista de Investigações Constitucionais
This article outlines the public architecture of social services in Spain from the perspective of the constitutional guarantee of the provision of local social services.
Maria Victòria Forns i Fernández   +1 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

The Application of Principal Component Analysis (PCA) for the Study of the Spanish Tourist Demand

open access: yesQuaestiones Geographicae, 2018
The objective of this study is the characterisation of the Spanish autonomous communities as tourist destinations for Spanish trips, based on the activities carried out, using the principal component method.
González González María Jesús   +1 more
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

The Territorialisation of Social Inclusion Policies from the Perspective of the Spanish Rural Areas: Regional Comparative

open access: yesRevista de Estudios Andaluces, 2020
This article explores how the attention to rural areas is materialised in the plans for social inclusion in Spain. We analyse the national and autonomous frameworks classifying the Autonomous Communities (AACC) according to their degree of rurality (OCDE)
Jaime Escribano-Pizarro   +2 more
doaj   +3 more sources

La distribución de competencias en materia energética: bloque de constitucionalidad y jurisprudencia constitucional

open access: yesRevista Vasca de Administración Pública, 2014
This paper analyses the allocation of competences between the state and the autonomous communities in the field of energy. First, it revisits the different legal bases of intervention that the constitution and the autonomy statutes recognise to the state
Xabier Arzoz Santisteban
doaj   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

open access: yesFEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli   +9 more
wiley   +1 more source

Patterns, Trends and Policy Processes in Spanish Secondary Education: Multiple Streams in a Multilevel Context

open access: yesCentral European Public Administration Review, 2014
Educational policies in Spain have been characterized by conflict and continuous changes to legislation in the Central State. However, Spain is a decentralized State and the Autonomous Communities (regions) are responsible for implementing secondary ...
Eliseo López Sánchez, Esther del Campo
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

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