Results 61 to 70 of about 3,743,259 (308)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Derechos y libertades y Estado de las Autonomías
Revista Vasca de Administración Pública, 2010 The descentralization of Spain which began in the constituant process meant a new territorial model of State, in-between a federal State and a centralized one.
M.ª Isabel Álvarez Vélez +2 more
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Semantic Self-Formation of Communities of Peers [PDF]
, 2005 The formation of semantic communities of peers plays a crucial role for realizing effective query propagation mechanisms on a semantic basis. In this paper, we propose a novel approach to the self-organization of autonomous communities of peers; we ...
S. Montanelli, S. Castano
core +1 more source
« Etat composé » ou décomposé ?
L'Espace Politique, 2010 The Spanish Constitution of 1978 shares the power between the State and the Autonomous Communities. Over the past three decades, the principle of this "compound state" has become reality.
Nacima Baron
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Revista de Investigações ConstitucionaisThis article outlines the public architecture of social services in Spain from the perspective of the constitutional guarantee of the provision of local social services.
Maria Victòria Forns i Fernández +1 more
doaj +1 more source
Coordination of autonomic functionalities in communications networks
CoRR, 2012 Future communication networks are expected to feature autonomic (or self-organizing) mechanisms to ease deployment (self-configuration), tune parameters automatically (self-optimization) and repair the network (self-healing). Self-organizing mechanisms have been designed as stand-alone entities, even though multiple mechanisms will run in parallel in ...
Combes, Richard +2 more
openaire +4 more sources
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Spanish regional offices in Brussels: are they vital for effective participation in the EU?
Revista CIDOB d'Afers Internacionals, 2012 The agreements signed at the Conference for EU-Related Affairs (CARUE) in November 2004 represented an attempt to ensure the formal participation of Spain’s autonomous communities in the Council of the EU and its preparatory bodies.
Mirna Nouvilas Rodrigo
doaj