Results 81 to 90 of about 11,171 (260)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A non-autonomous Leslie–Gower model with Holling type IV functional response and harvesting complexity

Advances in Difference Equations, 2019
This paper considers a non-autonomous modified Leslie–Gower model with Holling type IV functional response and nonlinear prey harvesting. The permanence of the model is obtained, and sufficient conditions for the existence of a periodic solution are ...
Jie Song, Yonghui Xia, Yuzhen Bai, Yaoxiong Cai, D. O’Regan   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Autonomous Self-Propelled Napa Cabbage Harvester: Cutting, Attitude Control, and Loading Modules

Agriculture
This paper introduces an autonomous self-propelled Napa cabbage harvester, designed to significantly improve the efficiency and effectiveness of the traditionally labor-intensive harvesting process.
Yonghyun Park, Myeong-Sin Kim, Juwon Shin, Yongjin Cho, Hyuck-Joo Kim, Hyoung Il Son   +5 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Miniature autonomous humanoid robot for environmental sensing and atmospheric water harvesting using bioinspired materials and AI-based vision

Applied Water Science
This study presents a miniature autonomous humanoid robotic system that not only performs real-time environmental monitoring and atmospheric water harvesting in extreme and unstructured environments, but also introduces several novel system-level ...
Hwa-Dong Liu, Chen-Wei Su, Chia-Hsun Chang, Cheng-Ze Li, Ping-Jui Lin   +4 more
doaj   +1 more source

Recent Start-Up Techniques Intended for TEG Energy Harvesting: A Review

IEEE Access
The growing number of energy-autonomous applications raises the need for reliable DC energy harvesting techniques such as Thermoelectric Generators (TEGs).
Mahmoud Ahmed, Sebastien Genevey, Mohamed Ali, Yvon Savaria, Yves Audet   +4 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

An Integrated System of Bulk Tea Harvesting Robot With Profiling Logic

IEEE Access
There is a growing demand for tea harvesting robots due to the harsh harvesting environment and rising in labor costs. Despite considerable efforts by the research community, the robustness to hilly field environment and the harvesting efficiency of the ...
Wenyu Yi, Pan Wang, Zhi Xu, Sicheng Dong, Guangshuai Liu   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source