Results 151 to 160 of about 175,264 (259)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Molecular and functional characterization of the B-cell receptor in chronic lymphocytic leukemia-like monoclonal B-cell lymphocytosis. [PDF]

Leukemia
Agathangelidis A, Iatrou A, Pechlivanis N, Karakatsoulis G, Zaragoza-Infante L, Galigalidou C, Maity PC, Ranghetti P, Almeida J, Fuentes-Herrero B, Navarro A, Alcoceba M, Rabbani L, Thorvaldsdottir B, Scarfò L, Orfao A, Psomopoulos F, Jumaa H, Rosenquist R, Chatzidimitriou A, Ghia P, Stamatopoulos K.   +21 more
europepmc   +1 more source

Autonomous Oceanographic Sampling Networks [PDF]

Oceanography, 1993
Thomas Curtin, James Bellingham, Josko Catipovic, Doug Webb   +3 more
openaire   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Regional inequalities in heart failure hospitalisation and in-hospital mortality in Spain (2016-2022): a nationwide, observational study. [PDF]

Lancet Reg Health Eur
Ortiz-Cortés C, Fernández-Friera L, Gámez JM, Cequier Fillat Á, Bonanad Lozano C, Sambola A, Fácila Rubio L, Rodríguez Padial L, Campuzano Ruíz R, Pedreira Pérez M, de la Torre Hernández JM, Rosillo N, Sánchez Fernández S, Del Prado N, Bernal JL, Fernández Pérez C, Alvaredo D, Rico-Martín S, Elola-Somoza FJ.   +18 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Biomimetic Digital Twin of Future Embodied Internet for Advancing Autonomous Vehicles and Robots. [PDF]

Biomimetics (Basel)
Xie M, Wang X.
europepmc   +1 more source

Harnessing technology: The learner and their context Increasingly autonomous: learners using technology in the context of their family lives and beyond - 14 individual case studies [PDF]

, 2009
Cranmer, Sue, Davies, Chris, Good, Jenny
core  

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Cluster Networking and Cooperative Localization Based on Biogeography Optimization and Improved Super-Multidimensional Scaling for Multi-Unmanned Aerial Vehicles. [PDF]

Sensors (Basel)
Zhang S, Zhang H, Zhan Y, Wei X, Liu Y.
europepmc   +1 more source