Autophagy and autophagy-related proteins in cancer [PDF]
Molecular Cancer, 2020 Autophagy, as a type II programmed cell death, plays crucial roles with autophagy-related (ATG) proteins in cancer. Up to now, the dual role of autophagy both in cancer progression and inhibition remains controversial, in which the numerous ATG proteins ...
Xiaohua Li, Shikun He, Binyun Ma
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Biological functions of the autophagy-related proteins Atg4 and Atg8 in Cryptococcus neoformans. [PDF]
PLoS ONE, 2020 Autophagy is a mechanism responsible for intracellular degradation and recycling of macromolecules and organelles, essential for cell survival in adverse conditions.
Thiago Nunes Roberto +4 more
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Chemical Biology of Autophagy-Related Proteins With Posttranslational Modifications: From Chemical Synthesis to Biological Applications [PDF]
Frontiers in Chemistry, 2020 Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved lysosomal degradation pathway in all eukaryotic cells, which is critical for maintaining cell homeostasis. A series of autophagy-related (ATG) proteins are involved in the
Yu Luo, Chen Jiang, Lihua Yu, Aimin Yang
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Systematic identification of autophagy-related proteins in Aedes albopictus. [PDF]
PLoS ONE, 2021 Autophagy is a conserved cellular process playing a role in maintenance of cellular homeostasis and response to changing nutrient conditions via degradation and recirculation of cellular redundant components.
Yu Wang +9 more
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Metformin inhibits the apoptosis of intervertebral disc tissue cells in rabbit model with lumbar intervertebral disc degeneration [PDF]
Jichu yixue yu linchuang, 2023 Objective To investigate the impacts of metformin on autophagy and inflammation of intervertebral disc tissue in rabbits, so as to preliminarily explore the molecular mechanism of its anti-intervertebral disc degeneration.
DONG Junli, CAI Shaokang, YAN Lei, CAI Yi
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Orthopaedic Surgery, 2022 Objective To investigate the effect of autophagy expression levels of different weight‐bearing states and different stages of osteoarthritis in animal models, as well as the corresponding mechanisms.
Shao‐long Zhang +7 more
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A Structural Approach into Drug Discovery Based on Autophagy
Life, 2021 Autophagy is a lysosome-dependent intracellular degradation machinery that plays an essential role in the regulation of cellular homeostasis. As many studies have revealed that autophagy is related to cancer, neurodegenerative diseases, metabolic ...
Sung-Min Kang, Do-Hee Kim
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Inhibition of Connexin 43 reverses ox-LDL-mediated inhibition of autophagy in VSMC by inhibiting the PI3K/Akt/mTOR signaling pathway [PDF]
PeerJ, 2022 Background Oxidized low-density lipoproteins (ox-LDL) may induce foam cell formation from the vascular smooth muscle cell (VSMC) by inhibiting VSMC autophagy. This process accelerates the formation of atherosclerosis (AS).
Xuqing Qin +8 more
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Golgi Apparatus: A Potential Therapeutic Target for Autophagy-Associated Neurological Diseases
Frontiers in Cell and Developmental Biology, 2020 Autophagy has dual effects in human diseases: appropriate autophagy may protect cells from stress, while excessive autophagy may cause cell death. Additionally, close interactions exist between autophagy and the Golgi.
Shuwen Deng, Jia Liu, Xiaomei Wu, Wei Lu
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MIR376A is a regulator of starvation-induced autophagy [PDF]
, 2013 Background: Autophagy is a vesicular trafficking process responsible for the degradation of long-lived, misfolded or abnormal proteins, as well as damaged or surplus organelles.
Ali Kosar +60 more
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