Brazilian Journal of Medical and Biological Research, 2018 Andrographolide (ANDRO) has been studied for its immunomodulation, anti-inflammatory, and neuroprotection effects. Because brain hypoxia is the most common factor of secondary brain injury after traumatic brain injury, we studied the role and possible ...
Juan Du +6 more
doaj +1 more source
Inhibition of Autophagy Signaling via 3-methyladenine Rescued Nicotine-Mediated Cardiac Pathological Effects and Heart Dysfunctions. [PDF]
, 2020 Rationale: Cigarette smoking is a well-established risk factor for myocardial infarction and sudden cardiac death. The deleterious effects are mainly due to nicotine, but the mechanisms involved and theranostics remain unclear.
Fu, Yingjie +7 more
core
HAMdb: a database of human autophagy modulators with specific pathway and disease information
Journal of Cheminformatics, 2018 Autophagy is an important homeostatic cellular recycling mechanism responsible for degrading unnecessary or dysfunctional cellular organelles and proteins in all living cells.
Ning-Ning Wang +7 more
doaj +1 more source
Autophagy as a Vital Therapy Target for Renal Cell Carcinoma
Frontiers in Pharmacology, 2021 Autophagy is a process that degrades and recycles superfluous organelles or damaged cellular contents. It has been found to have dual functions in renal cell carcinoma (RCC).
Ying-hua He, Guo Tian
doaj +1 more source
FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates [PDF]
, 2019 The autophagy cargo receptor p62 facilitates the condensation of misfolded, ubiquitin-positive proteins and their degradation by autophagy, but the molecular mechanism of p62 signaling to the core autophagy machinery is unclear.
Abert, Christine +9 more
core +1 more source
Autophagy-dependent ferroptosis is involved in the development of endometriosis
Gynecological Endocrinology, 2023 Objective Endometriosis (EMS) is an estrogen-dependent condition with unclear pathogenesis. Recent findings suggest implicate autophagy and ferroptosis in EMS development.Methods We assessed autophagy and ferroptosis proteins in EMS patients using ...
Hui Li +5 more
doaj +1 more source
Age-related deficits in skeletal muscle recovery following disuse are associated with neuromuscular junction instability and ER stress, not impaired protein synthesis. [PDF]
, 2016 Age-related loss of muscle mass and strength can be accelerated by impaired recovery of muscle mass following a transient atrophic stimulus. The aim of this study was to identify the mechanisms underlying the attenuated recovery of muscle mass and ...
Baar, Keith +6 more
core +2 more sources
WIPI-Mediated Autophagy and Longevity
Cells, 2015 Autophagy is a lysosomal degradation process for cytoplasmic components, including organelles, membranes, and proteins, and critically secures eukaryotic cellular homeostasis and survival.
Mona Grimmel +2 more
doaj +1 more source
In-depth proteomics identifies a role for autophagy in controlling reactive oxygen species mediated endothelial permeability [PDF]
, 2016 Endothelial cells (ECs) form the inner layer of blood vessels and physically separate the blood from the surrounding tissue. To support tissues with nutrients and oxygen, the endothelial monolayer is semipermeable.
Anderson, Kurt I. +7 more
core +10 more sources
Targeting autophagy-related protein kinases for potential therapeutic purpose
Acta Pharmaceutica Sinica B, 2020 Autophagy, defined as a scavenging process of protein aggregates and damaged organelles mediated by lysosomes, plays a significant role in the quality control of macromolecules and organelles. Since protein kinases are integral to the autophagy process, it is critically important to understand the role of kinases in autophagic regulation.
Honggang Xiang +5 more
openaire +3 more sources