Results 11 to 20 of about 103,155 (374)

Neonatal cerebrovascular autoregulation [PDF]

Pediatric Research, 2018
Cerebrovascular pressure autoregulation is the physiologic mechanism that holds cerebral blood flow (CBF) relatively constant across changes in cerebral perfusion pressure (CPP). Cerebral vasoreactivity refers to the vasoconstriction and vasodilation that occur during fluctuations in arterial blood pressure (ABP) to maintain autoregulation.
C. Rhee, Cristine Sortica da Costa, T. Austin, K. Brady, M. Czosnyka, Jennifer K. Lee   +5 more
semanticscholar   +3 more sources

Losing the dogmatic view of cerebral autoregulation

Physiological Reports, 2021
In 1959, Niels Lassen illustrated the cerebral autoregulation curve in the classic review article entitled Cerebral Blood Flow and Oxygen Consumption in Man.
P. Brassard, Lawrence Labrecque, Jonathan D. Smirl, M. Tymko, H. Caldwell, R. Hoiland, S. Lucas, A. Denault, É. Couture, P. Ainslie   +9 more
semanticscholar   +1 more source

Autoregulation of Neurogenesis by GDF11 [PDF]

Neuron, 2003
In the olfactory epithelium (OE), generation of new neurons by neuronal progenitors is inhibited by a signal from neurons themselves. Here we provide evidence that this feedback inhibitory signal is growth and differentiation factor 11 (GDF11). Both GDF11 and its receptors are expressed by OE neurons and progenitors, and GDF11 inhibits OE neurogenesis ...
Hsiao‐Huei Wu, Sanja Ivković, Richard C. Murray, Sylvia Jaramillo, Karen M. Lyons, Jane E. Johnson, Anne L. Calof   +6 more
openalex   +5 more sources

TDP-43 Oligomerization and Phase Separation Properties Are Necessary for Autoregulation

Frontiers in Neuroscience, 2022
Loss of TDP-43 protein homeostasis and dysfunction, in particular TDP-43 aggregation, are tied to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
L. Koehler, Z. Grese, Alliny C S Bastos, L. D. Mamede, T. Heyduk, Yuna M. Ayala   +5 more
semanticscholar   +1 more source

Impact of impaired cerebral blood flow autoregulation on cognitive impairment

Frontiers in Aging, 2022
Although the causes of cognitive impairment are multifactorial, emerging evidence indicates that cerebrovascular dysfunction plays an essential role in dementia.
Shaoxun Wang, Chengyun Tang, Yedan Liu, Jane J. Border, Richard J. Roman, Fan Fan   +5 more
semanticscholar   +1 more source

Comparison of different metrics of cerebral autoregulation in association with major morbidity and mortality after cardiac surgery.

British Journal of Anaesthesia, 2022
BACKGROUND Cardiac surgery studies have established the clinical relevance of personalised arterial blood pressure management based on cerebral autoregulation. However, variabilities exist in autoregulation evaluation.
Xiuyun Liu, J. Donnelly, K. Brady, K. Akiyoshi, Brian Bush, R. Koehler, Jennifer K. Lee, C. Hogue, M. Czosnyka, P. Smielewski, Charles H. Brown   +10 more
semanticscholar   +1 more source

Effects of subjective and objective autoregulation methods for intensity and volume on enhancing maximal strength during resistance-training interventions: a systematic review

PeerJ, 2021
Background Maximal strength is a critical determinant of performance in numerous sports. Autoregulation is a resistance training prescription approach to adjust training variables based on the individuals’ daily fluctuations in performance, which are a ...
Stian Larsen, E. Kristiansen, R. van den Tillaar   +2 more
semanticscholar   +1 more source

Fixed Compared With Autoregulation-Oriented Blood Pressure Thresholds After Mechanical Thrombectomy for Ischemic Stroke

Stroke, 2020
Supplemental Digital Content is available in the text. Background and Purpose— Loss of cerebral autoregulation in the acute phase of ischemic stroke leaves patients vulnerable to blood pressure (BP) changes.
N. Petersen, Andrew Silverman, S. Strander, Sreeja Kodali, Anson Wang, Lauren H. Sansing, J. Schindler, G. Falcone, E. Gilmore, Adam S. Jasne, B. Cord, R. Hebert, Michele H Johnson, C. Matouk, K. Sheth   +14 more
semanticscholar   +1 more source

Coupling metabolic addiction with negative autoregulation to improve strain stability and pathway yield

bioRxiv, 2020
Metabolic addiction, an organism that is metabolically addicted with a compound to maintain its growth fitness, is an underexplored area in metabolic engineering.
Yongkun Lv, Yang Gu, Jingliang Xu, Jingwen Zhou, Peng Xu   +4 more
semanticscholar   +1 more source

FUS ALS-causative mutations impair FUS autoregulation and splicing factor networks through intron retention

Nucleic Acids Research, 2020
Mutations in the RNA-binding protein FUS cause amyotrophic lateral sclerosis (ALS), a devastating neurodegenerative disease. FUS plays a role in numerous aspects of RNA metabolism, including mRNA splicing.
J. Humphrey, N. Birsa, Carmelo Milioto, Martha F McLaughlin, A. Ule, D. Robaldo, A. B. Eberle, Rahel Kräuchi, Matthew Bentham, Anna L. Brown, Seth Jarvis, C. Bodo, M. G. Garone, A. Devoy, G. Soraru', A. Rosa, I. Bozzoni, E. Fisher, O. Mühlemann, G. Schiavo, M. Ruepp, A. Isaacs, V. Plagnol, P. Fratta   +23 more
semanticscholar   +1 more source