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Autosomal dominant polycystic kidney disease [PDF]

Disease-a-Month, 2015
Autosomal dominant polycystic kidney disease (ADPKD) is an inherited disease of the kidneys that can cause an irreversible decline in kidney function leading to end-stage renal disease. It is one of the most common hereditary disorders. It is 10 times more common than sickle cell disease and 20 times more common than Huntington's disease.
Edgar V. Lerma, Jonathan Silverman, Chaitanya Desai   +2 more
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Autosomal dominant polycystic kidney disease

BMJ, 2016
#### What you need to know Polycystic kidney disease (PKD) is an inherited condition defined by the pathological development of fluid-filled cysts throughout the kidneys leading to organ enlargement (fig 1⇓) and chronic kidney disease. Autosomal dominant polycystic kidney disease (ADPKD) is the commonest inherited kidney disease1 and is the fourth ...
R. Simms
semanticscholar   +4 more sources

Autosomal dominant polycystic kidney disease

Drugs of the Future, 2006
Autosomal dominant polycystic kidney disease (ADPKD) is the most common form of polycystic kidney diseases, which are genetic disorders characterized by the abnormal growth of numerous cysts in the kidneys. ADPKD is one of the leading causes of end-stage
E. Ferrer, J. Bozzo
semanticscholar   +4 more sources

Autosomal Dominant Polycystic Kidney Disease

Primary Care: Clinics in Office Practice, 2020
Autosomal Dominant Polycystic Kidney Disease is an inherited multisystemic disorder of the renal tubules with subsequent formation of multiple cysts and enlargement of the kidney, affecting various organs. Diagnosis is initially suspected in those with family history and/or individuals who develop hypertension early on (secondary hypertension) or ...
Parvathi Perumareddi, Darin P. Trelka
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Assessing Risk of Rapid Progression in Autosomal Dominant Polycystic Kidney Disease and Special Considerations for Disease-Modifying Therapy.

American Journal of Kidney Diseases, 2021
Autosomal Dominant Polycystic Kidney Disease is the most common inherited cause of kidney failure accounting for 5-10% of cases. Predicting which patient would progress rapidly to kidney failure is critical to assess the risk-benefit ratio of any ...
F. Chebib, V. Torres
semanticscholar   +1 more source

Metformin Improves Relevant Disease Parameters in an Autosomal Dominant Polycystic Kidney Disease Mouse Model.

AJP - Renal Physiology, 2021
Autosomal dominant polycystic kidney disease (ADPKD), caused by mutations in the PKD1 or PKD2 genes encoding polycystins, presents with progressive development of kidney cysts and eventual end-stage kidney disease (ESKD) with limited treatment options ...
N. Pastor-Soler, Hui Li, Jessica Pham, Daniel Rivera, Pei‐Yin Ho, V. Mancino, Biagio Saitta, K. Hallows   +7 more
semanticscholar   +1 more source

Prescribed Water Intake in Autosomal Dominant Polycystic Kidney Disease

NEJM Evidence, 2021
Prescribed Water Intake in Autosomal Dominant Polycystic Kidney Disease The effect of increased water intake on kidney cyst growth in patients with polycystic kidney disease was compared for two groups randomly assigned to either prescribed or ad libitum
Gopi Rangan, Annette Wong, A. Munt, Jennifer Zhang, S. Saravanabavan, Margaret Allman-Farinelli, Sunil V Badve, Neil Boudville, Bradley J. Erickson, Mangalee R. Fernando, Sheryl L. Foster, Adriana Gregory, I. Haloob, Carmel M. Hawley, David W. Johnson, Timothy L. Kline, Vincent W. Lee, Maureen A. Lonergan, Elaine Pascoe, A. Rangan, Simon D Roger, Kamal Sud, Vicente E. Torres, Sundareswari V. Adinarayanan, D. Harris   +24 more
semanticscholar   +1 more source

Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease

Science Translational Medicine, 2020
Pharmacological induction of NRF2 restores redox homeostasis and slows cystogenesis in mouse models of polycystic kidney disease. Antioxidants dominate ADPKD Autosomal dominant polycystic kidney disease (ADPKD) is a relatively common genetic disorder ...
Yi Lu, Yongzhan Sun, Zhiheng Liu, Yumei Lu, Xu Zhu, Bingxue Lan, Zeyun Mi, Lin Dang, Na Li, Wenlei Zhan, Lu Tan, J. Pi, H. Xiong, Lirong Zhang, Yupeng Chen   +14 more
semanticscholar   +1 more source

Angiogenesis and autosomal dominant polycystic kidney disease

Pediatric Nephrology, 2012
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the growth of multiple cysts that in many cases result in end-stage renal disease. Current strategies to reduce cyst progression in ADPKD focus on modulating cell turnover, fluid secretion, and vasopressin signalling; but an alternative approach may be to target pathways providing
Huang, JL, Woolf, AS, Long, DA
openaire   +4 more sources

Diagnosis of autosomal dominant polycystic kidney disease

Expert Opinion on Medical Diagnostics, 2008
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease and accounts for 5 - 10% of end stage renal disease. Mutations of two genes, PKD1 and PKD2, account for ∼ 85 and ∼ 15% of cases, respectively.This paper reviews the clinical features of ADPKD, highlights the current roles for image- and molecular-based ...
York Pei, Xiao Zhao
openaire   +3 more sources