Results 51 to 60 of about 149,259 (318)
, 2017 This chapter is dedicated to the main renal anomalies detectable by ultrasound. Anomalies of the lower urinary tract will be addressed in a separate chapter.
Barbu, Madalina +5 more
core +2 more sources
Metabolism-based approaches for autosomal dominant polycystic kidney disease
Frontiers in Molecular Biosciences, 2023 Autosomal Dominant Polycystic Kidney Disease (ADPKD) leads to end stage kidney disease (ESKD) through the development and expansion of multiple cysts throughout the kidney parenchyma.
Ivona Bakaj, Alessandro Pocai
doaj +1 more source
The tyrosine-kinase inhibitor Nintedanib ameliorates autosomal-dominant polycystic kidney disease
Cell Death and Disease, 2021 Autosomal-dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease and is characterized by progressive growth of fluid-filled cysts. Growth factors binding to receptor tyrosine kinases (RTKs) stimulate cell proliferation and
Abeda Jamadar +6 more
semanticscholar +1 more source
Pkd2 dosage influences cellular repair responses following ischemia-reperfusion injury [PDF]
, 2009 Autosomal dominant polycystic kidney disease (ADPKD) results from mutations in either PKD1 or PKD2 and accounts for 10% of all patients on renal replacement therapy. The kidney disease phenotype is primarily characterized by cyst formation, but there are
Haylor, J.L. +4 more
core +2 more sources
AMPK and Polycystic Kidney Disease Drug Development: An Interesting Off-Target Target
Frontiers in Medicine, 2022 Autosomal Dominant Polycystic Kidney Disease is a genetic disease that causes dramatic perturbations of both renal tissue architecture and of a multitude of cellular signaling pathways.
Michael J. Caplan
doaj +1 more source
De-biased lasso for stratified Cox models with application to the national kidney transplant data [PDF]
arXiv, 2022 The Scientific Registry of Transplant Recipients (SRTR) system has become a rich resource for understanding the complex mechanisms of graft failure after kidney transplant, a crucial step for allocating organs effectively and implementing appropriate care.
arxiv
American Society of Nephrology. Clinical Journal, 2020 Autosomal dominant polycystic kidney disease is characterized by progressive development and enlargement of kidney cysts, leading to ESKD. Because the kidneys are under high metabolic demand, it is not surprising that mounting evidence suggests that a ...
Kristen L. Nowak, K. Hopp
semanticscholar +1 more source
Role of Image Acquisition and Patient Phenotype Variations in Automatic Segmentation Model Generalization [PDF]
arXiv, 2023 Purpose: This study evaluated the out-of-domain performance and generalization capabilities of automated medical image segmentation models, with a particular focus on adaptation to new image acquisitions and disease type. Materials: Datasets from both non-contrast and contrast-enhanced abdominal CT scans of healthy patients and those with polycystic ...
arxiv
Journal of the American Society of Nephrology, 2015 The rate of renal disease progression varies widely among patients with autosomal dominant polycystic kidney disease (ADPKD), necessitating optimal patient selection for enrollment into clinical trials.
M. Irazabal +15 more
semanticscholar +1 more source
Insights into Autosomal Dominant Polycystic Kidney Disease from Genetic Studies.
American Society of Nephrology. Clinical Journal, 2020 Autosomal dominant polycystic kidney disease is the most common monogenic cause of ESKD. Genetic studies from patients and animal models have informed disease pathobiology and strongly support a "threshold model" in which cyst formation is triggered by ...
M. Lanktree +4 more
semanticscholar +1 more source