Results 61 to 70 of about 42,420 (251)
, 2017 This chapter is dedicated to the main renal anomalies detectable by ultrasound. Anomalies of the lower urinary tract will be addressed in a separate chapter.
Barbu, Madalina +5 more
core +2 more sources
Role of CFTR in Autosomal Recessive Polycystic Kidney Disease [PDF]
Journal of the American Society of Nephrology, 2001 Abstract. An extensive body of in vitro data implicates epithelial chloride secretion, mediated through cystic fibrosis transmembrane conductance regulator (CFTR) protein, in generating or maintaining fluid filled cysts in MDCK cells and in human autosomal dominant polycystic kidney disease (ADPKD).
Ellis D. Avner +4 more
openaire +2 more sources
Modeling Vascular Branching Alterations in Polycystic Kidney Disease [PDF]
arXiv, 2022 The analysis of biological networks encompasses a wide variety of fields from genomic research of protein-protein interaction networks, to the physiological study of biologically optimized tree-like vascular networks. It is certain that different biological networks have different optimization criteria and we are interested in those networks optimized ...
arxiv
Embracing Sex-specific Differences in Engineered Kidney Models for Enhanced Biological Understanding [PDF]
, 2023 In vitro models play a crucial role in advancing our understanding of biological processes, disease mechanisms, and developing screening platforms for drug discovery. Kidneys play an instrumental role in transport and elimination of drugs and toxins.
arxiv +1 more source
Polycystic kidney disease: Clues to pathogenesis [PDF]
, 1991 Autosomal-dominant polycystic kidney disease (ADPKD), largely neglected for several decades, has emerged in recent years as the renal disease most likely to be understood from the gene to the patient.
Gabow, Patricia A.
core +1 more source
Transcriptional Complexity in Autosomal Recessive Polycystic Kidney Disease [PDF]
Clinical Journal of the American Society of Nephrology, 2014 Autosomal recessive polycystic kidney disease (ARPKD) is caused by mutations in the PKHD1 gene. The longest open reading frame comprises 66 exons encoding polyductin or fibrocystin, a type I transmembrane protein with 4074 amino acids. Functional investigations are considerably hampered by its large size and lack of expression in tissues that are ...
Carsten Bergmann +3 more
openaire +2 more sources
Effect of Heterogeneous Mixing and Vaccination on the Dynamics of Anthelmintic Resistance: A Nested Model [PDF]
Sabatelli L (2010) Effect of Heterogeneous Mixing and Vaccination
on the Dynamics of Anthelmintic Resistance: A Nested Model. PLoS ONE 5(5):
e10686. doi:10.1371/journal.pone.0010686, 2010 Anthelmintic resistance is a major threat to current measures for helminth control in humans and animals. The introduction of anthelmintic vaccines, as a complement to or replacement for drug treatments, has been advocated as a preventive measure. Here, a computer-based simulation, tracking the dynamics of hosts, parasites and parasite-genes, shows ...
arxiv +1 more source
Delayed diagnosis of Townes‑Brocks syndrome with multicystic kidneys and renal failure caused by a novel SALL1 nonsense mutation: A case report [PDF]
, 2016 Townes‑Brocks syndrome (TBS) is a rare autosomal dominant congenital anomaly syndrome characterized by the triad of anorectal, hand and external ear malformations. Kidney involvement is less common and may progress to end‑stage renal failure (ESRF) early
Bian, F +6 more
core +1 more source
Localization of overexpressed c-myc mRNA in polycystic kidneys of the cpk mouse [PDF]
, 1992 Localization of overexpressed c-myc mRNA in polycystic kidneys of the cpk mouse. The C57BL/6J-cpk mouse has a form of autosomal-recessive polycystic kidney disease characterized by the rapid growth of large collecting duct cysts and the development of ...
Calvet, James P. +3 more
core +1 more source
Diabetes, Obesity and Metabolism, EarlyView.Abstract Aims To evaluate whether type 2 diabetes status modifies the efficacy and safety of combining zibotentan (zibo), a selective endothelin receptor antagonist, and dapagliflozin (dapa) compared to placebo plus dapagliflozin in individuals with chronic kidney disease (CKD).
Victor Wasehuus +7 more
wiley +1 more source