Results 41 to 50 of about 872,348 (303)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The Study of Reproduction, Fecundity and Diet in 3 Species of Kilka in the Southern Part of the Caspian Sea (BoboIsar Region)

‬‭Majallah-i ̒Ilmī-i Shīlāt-i Īrān, 1997
Considering the large population of kilka in the Caspian Sea and their role in the survival of ecosystem, it is important to know their biological characteristics as a basic information in the fisheries research activities.
M. Naderi; H. Fazli; M. Afraei; A. Ganjian
doaj  

Seasonal reversal in phytoplankton assembly mechanisms: stochastic dominance in autumn vs. deterministic control in spring within the middle and lower reaches of the Yellow River

Frontiers in Microbiology
Phytoplankton communities play a crucial role in riverine ecosystems, yet their assembly mechanisms in high-silt environments remain poorly understood.
Dahai Zeng, Dahai Zeng, Dahai Zeng, Houkuan Ding, Houkuan Ding, Houkuan Ding, Yuanyuan Tang, Yuanyuan Tang, Yuanyuan Tang, Yunni Gao, Yunni Gao, Yunni Gao, Jialin Jin, Jialin Jin, Jialin Jin, Xiaofei Gao, Xiaofei Gao, Xiaofei Gao, Jingxiao Zhang, Jingxiao Zhang, Jingxiao Zhang, Huatao Yuan, Huatao Yuan, Huatao Yuan, Jing Dong, Jing Dong, Jing Dong, Xuejun Li, Xuejun Li, Xuejun Li   +29 more
doaj   +1 more source

An introduction to the abelian Reidemeister torsion of three-dimensional manifolds [PDF]

, 2010
These notes accompany some lectures given at the autumn school "Tresses in Pau" in October 2009. The abelian Reidemeister torsion for 3-manifolds, and its refinements by Turaev, are introduced.
Massuyeau, Gwenael
core   +3 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Outlook Magazine, Autumn 2014 [PDF]

, 2014
https://digitalcommons.wustl.edu/outlook/1193/thumbnail ...

core   +1 more source

Near-surface remote sensing of spatial and temporal variation in canopy phenology [PDF]

, 2009
There is a need to document how plant phenology is responding to global change factors, particularly warming trends. “Near-surface” remote sensing, using radiometric instruments or imaging sensors, has great potential to improve phenological monitoring ...
Braswell, Rob, Hollinger, David Y, Jenkins, J P, Ollinger, Scott V, Richardson, Andrew D.   +4 more
core   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Addressing cultural insensitivity in archival description

Journal of New Librarianship, 2020
Issues surrounding inappropriate language use in library cataloging and archival description have a history of discussion. This literature review examines biased language in library and archive use for collection description and explores collaborative ...
Autumn Wetli
doaj   +1 more source

Outlook Magazine, Autumn 2018 [PDF]

, 2018
https://digitalcommons.wustl.edu/outlook/1205/thumbnail ...

core   +1 more source