Results 91 to 100 of about 3,788,461 (324)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

UNIFIED FUNCTIONAL METHOD FOR SOLVING GENERAL POLYNOMIAL EQUATIONS OF DEGREE LESS THAN FIVE

Malaysian Journal of Computing, 2021
A unified method for solving general polynomial equation of degree less than five that incorporate a computational formula that relate the coefficients of the depressed equation and the coefficient of the standard polynomial equation is proposed in this ...
Dozie Felix Nwosu, Odilichukwu Christian Okoli, Amaka Ezeonyebuchi, Ababu Teklemariam Tiruneh   +3 more
doaj   +1 more source

Solitons and Other Solutions for Two Higher-Order Nonlinear Wave Equations of KdV Type Using the Unified Auxiliary Equation Method

Acta Physica Polonica. A, 2019
Many new types of Jacobi-elliptic function solutions, solitons, and other solutions for two nonlinear partial differential equations, namely, the higher-order wave equation of KdV type (III) and the higher-order wave equation of KdV type (II) have been ...
E. Zayed, R. Shohib
semanticscholar   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Auxiliary Linear Problem, Difference Fay Identities and Dispersionless Limit of Pfaff-Toda Hierarchy

Symmetry, Integrability and Geometry: Methods and Applications, 2009
Recently the study of Fay-type identities revealed some new features of the DKP hierarchy (also known as ''the coupled KP hierarchy'' and ''the Pfaff lattice'').
Kanehisa Takasaki
doaj   +1 more source

The Study of the Solution to a Generalized KdV-mKdV Equation

Abstract and Applied Analysis, 2013
A mathematical technique based on an auxiliary equation and the symbolic computation system Matlab is employed to investigate a generalized KdV-mKdV equation which possesses high-order nonlinear terms.
Xiumei Lv, Tengwei Shao, Jiacheng Chen
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

A New Method with a Different Auxiliary Equation to Obtain Solitary Wave Solutions for Nonlinear Partial Differential Equations

Advances in Mathematical Physics, 2013
A new method with a different auxiliary equation from the Riccati equation is used for constructing exact travelling wave solutions of nonlinear partial differential equations.
Bülent Kiliç, Hasan Bulut
doaj   +1 more source