Results 111 to 120 of about 3,788,461 (324)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Abstract and Applied Analysis, 2014 We consider the Lagrangian and the self-adjointness of a generalized regularized long-wave equation and its transformed equation. We show that the third-order equation has a nonlocal Lagrangian with an auxiliary function and is strictly self-adjoint; its
Long Wei, Yang Wang
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American Journal of Applied Mathematics and Statistics, 2018 In this article the new extension of the generalized and improved (G’/G)-expansion method has been used to generate many new and abundant solitons and periodic solutions, where the nonlinear ordinary differential equation has been used as an auxiliary ...
Anika Khan, Hasibun Naher
semanticscholar +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Қарағанды университетінің хабаршысы. Математика сериясыThe Ginzburg-Landau equation with rapidly oscillating terms in the equation and boundary conditions in a perforated domain was considered. Proof was given that the trajectory attractors of this equation converge weakly to the trajectory attractors of ...
K.A. Бекмаганбетов +3 more
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Auxiliary branch method and modified nodal voltage equations [PDF]
Advances in Radio Science, 2008 Abstract. A theorem is presented describing a transformation by means of which it is possible to assign to an elementary multiport with fairly general constitutive equations (including all kinds of controlled sources, nullors, ideal transformers, etc.) a modified multiport with the same all-pole terminal behavior.
openaire +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source