Results 71 to 80 of about 340,065 (284)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Full-wave parallel dispersive finite-difference time-domain modeling of three-dimensional electromagnetic cloaking structures

, 2009
A parallel dispersive finite-difference time-domain (FDTD) method for the modeling of three-dimensional (3-D) electromagnetic cloaking structures is presented in this paper.
Berenger, Blanchard, Bower, Cai, Cai, Chen, Chen, Chen, Chew, Cummer, Gandhi, Gedney, Hildebrand, Huang, Lee, Leonhardt, Liang, Luebbers, Luo, Luo, Pendry, Rahm, Ruan, Schurig, Schurig, Sullivan, Taflove, Tsang, Vasic, Yan, Yan Zhao, Yang Hao, Yee, Zhang, Zhang, Zhao, Zhao   +36 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

The modified homotopy perturbation method with an auxiliary term for the nonlinear oscillator with discontinuity

Journal of Low Frequency Noise, Vibration and Active Control, 2019
Recently, a modified homotopy perturbation method with an auxiliary term was proposed for obtaining an analytical approximate solution of a nonlinear equation.
Syed Ahmed Pasha, Yasir Nawaz, Muhammad Shoaib Arif   +2 more
doaj   +1 more source

Test-field method for mean-field coefficients with MHD background

, 2010
Aims: The test-field method for computing turbulent transport coefficients from simulations of hydromagnetic flows is extended to the regime with a magnetohydrodynamic (MHD) background.
Brandenburg, A., Rheinhardt, M.
core   +3 more sources

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Symmetry Reduced and New Exact Nontraveling Wave Solutions of (2+1)-Dimensional Potential Boiti-Leon-Manna-Pempinelli Equation

Abstract and Applied Analysis, 2013
With the aid of Maple symbolic computation and Lie group method, (2+1)-dimensional PBLMP equation is reduced to some (1+1)-dimensional PDE with constant coefficients. Using the homoclinic test technique and auxiliary equation methods, we obtain new exact
Chen Han-Lin, Xian Da-Quan
doaj   +1 more source

Ion acoustic solitary wave solutions of three-dimensional nonlinear extended Zakharov–Kuznetsov dynamical equation in a magnetized two-ion-temperature dusty plasma

Results in Physics, 2016
We consider the propagation of three-dimensional nonlinear magnetized two-ion-temperature dusty plasma. The problem formulation of this mathematical model leads to nonlinear extended Zakharov–Kuznetsov (EZK) dynamical equation in three-dimensional by ...
Aly R. Seadawy, Dianchen Lu
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Soliton dynamics of the KdV–mKdV equation using three distinct exact methods in nonlinear phenomena

Nonlinear Engineering
The KdV–mKdV equation is investigated in this study. This equation is a useful tool to model many nonlinear phenomena in the fields of fluid dynamics, quantum mechanics, and soliton wave theory.
Ullah M. Atta, Rehan Kashif, Perveen Zahida, Sadaf Maasoomah, Akram Ghazala   +4 more
doaj   +1 more source