Results 121 to 130 of about 811,009 (286)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Coded speech enhancement using auxiliary utterance-level information
EURASIP Journal on Audio, Speech, and Music ProcessingNumerous post-processing methods have been proposed to improve coded speech quality and intelligibility. However, achieving state-of-the-art enhancement and generalisation across varying distortion levels remains a challenge.
Haixin Zhao, Nilesh Madhu
doaj +1 more source
Conditional inference with a complex sampling: exact computations and Monte Carlo estimations
, 2012 In survey statistics, the usual technique for estimating a population total consists in summing appropriately weighted variable values for the units in the sample.
Coquet, François, Lesage, Éric
core +1 more source
Enhanced Item Recommendation with Auxiliary Information
, 2023 Recommender systems have been deployed in many diverse settings, and they aim to provide a personalized ranked list of items to users that they are likely to interact with. In order to provide an accurate list of items, models need to capture various aspects of the users' profiles, behaviors, and items' dynamics.
openaire +2 more sources
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Métodos de imputación para el tratamiento de datos faltantes: aplicación mediante R/Splus = Imputation methods to handle the problem of missing data: an application using R/Splus [PDF]
Revista de Métodos Cuantitativos para la Economía y la Empresa, 2009 La aparición de datos faltantes es un problema común en la mayoría de las encuestas llevadas a cabo en distintos ámbitos. Una técnica tradicional y muy conocida para el tratamiento de datos faltantes es la imputación.
Muñoz Rosas, Juan Francisco +1 more
doaj
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
DP With Auxiliary Information: Gaussian Mechanism Versus Laplacian Mechanism
IEEE Open Journal of the Communications SocietyDifferential privacy (DP) has been widely used in communication systems, especially those using federated learning or distributed computing. DP comes in the data preparation stage before line coding and transmission.
Wessam Mesbah
doaj +1 more source
Incorporating Multivariate Auxiliary Information for Traffic Prediction on Highways. [PDF]
Sensors (Basel), 2023 Li B, Xiong J, Wan F, Wang C, Wang D.
europepmc +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source