Results 81 to 90 of about 24,615,903 (307)
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Applied Sciences, 2018 Energy storage providing auxiliary service at the user-side has broad prospects in support of national polices. Three auxiliary services are selected as the application scene for energy storage participating in demand management, peak shaving and demand ...
Lijuan Chen, Tiantian Wu, Xiaohui Xu
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
EnergiesTo address the issue of high auxiliary service costs caused by the grid connection of new energy generation, a dual layer optimization scheduling method for high penetration new energy power grids is proposed, taking into account the auxiliary service ...
Renfeng Tao, Fengting Li, Yangqing Li
doaj +1 more source
Numerical Investigation on Rock-Fracturing Mechanism by Using Splitter under Hole Assistance
Shock and Vibration, 2019 In this work, a numerical model of rock breaking under hole assistance was established based on the finite element method (FEM) coupling with smoothed particle hydrodynamics (SPH) to reveal rock-breaking mechanisms and analyze the reasons for crack ...
Hongsheng Li +3 more
doaj +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Simulation Training Auxiliary Model Based on Neural Network and Virtual Reality Technology. [PDF]
Comput Intell Neurosci, 2022 Liu W.
europepmc +1 more source
Auxiliary field methods in supersymmetric non-linear sigma models [PDF]
Nuclear Physics B, 2005 Auxiliary field methods in D=2 (or 3), N=2 supersymmetric (SUSY) nonlinear sigma models (NLSMs) are studied. For these models auxiliary fields as Lagrange multipliers belong to a vector or a chiral superfield, which gives a Kahler quotient of complexified gauge group or a holomorphic constraint on it, respectively.
openaire +2 more sources
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source