Results 11 to 20 of about 709 (109)
Distortion in the Communication of Nonsignificant Primary Outcomes: The Spin Strategy in Multiple Sclerosis Trials. [PDF]
Ann NeurolObjective Spin refers to reporting strategies that highlight the benefits of an experimental treatment or divert attention from nonsignificant primary outcomes. We aimed to assess spin in randomized controlled trials (RCTs) on pharmaceutical efficacy in multiple sclerosis (MS) and explore associated factors.
Mascareñas-García M +10 more
europepmc +2 more sources
Intervenção de esportes modificados para melhorar metas de participação e competências de atividade em crianças deambuladoras com paralisia cerebral: um ensaio clínico randomizado. [PDF]
Dev Med Child NeurolIntervenções de esportes modificados para crianças com Paralisia Cerebral: Resumo gráfico. Resumo Objetivo Avaliar a eficácia de uma intervenção de esportes modificados (Sports Stars Brasil) nos objetivos de participação em atividades físicas de lazer, desempenho e capacidade motora, funções corporais, níveis de atividade física, alfabetização física e
Sousa Junior RR +7 more
europepmc +2 more sources
The MegaPool Approach to Characterize Adaptive CD4+ and CD8+ T Cell Responses
Current Protocols, Volume 3, Issue 11, November 2023., 2023 Abstract Epitopes recognized by T cells are a collection of short peptide fragments derived from specific antigens or proteins. Immunological research to study T cell responses is hindered by the extreme degree of heterogeneity of epitope targets, which are usually derived from multiple antigens; within a given antigen, hundreds of different T cell ...
Ricardo da Silva Antunes +7 more
wiley +1 more source
Journal of Viral Hepatitis, Volume 30, Issue 3, Page 209-222, March 2023., 2023 Abstract Treatment for chronic hepatitis B virus infection (cHBV) is mostly indefinite, with new finite‐duration therapies needed. We report safety, pharmacokinetics and antiviral activity of the investigational HBV core inhibitor ABI‐H2158. This Phase 1a/b study (NCT03714152) had three parts: Part A, participants received a single ascending oral dose ...
Kosh Agarwal +17 more
wiley +1 more source
Detecting and reducing heterogeneity of error in acoustic classification
Methods in Ecology and Evolution, Volume 13, Issue 11, Page 2559-2571, November 2022., 2022 Abstract Passive acoustic monitoring can be an effective method for monitoring species, allowing the assembly of large audio datasets, removing logistical constraints in data collection and reducing anthropogenic monitoring disturbances. However, the analysis of large acoustic datasets is challenging and fully automated machine learning processes are ...
Oliver C. Metcalf +8 more
wiley +1 more source
Immunological memory to SARS‐CoV‐2 infection and COVID‐19 vaccines
Immunological Reviews, Volume 310, Issue 1, Page 27-46, September 2022., 2022 Abstract Immunological memory is the basis of protective immunity provided by vaccines and previous infections. Immunological memory can develop from multiple branches of the adaptive immune system, including CD4 T cells, CD8 T cells, B cells, and long‐lasting antibody responses.
Alessandro Sette, Shane Crotty
wiley +1 more source
The Journal of Clinical Hypertension, Volume 24, Issue 5, Page 555-565, May 2022., 2022 Abstract This study aimed to develop and validate an instrument to assess Brazilian adults’ knowledge, perceptions, and behaviors (KPB) toward salt and sodium. Based on a PAHO/WHO questionnaire, a new instrument was developed and evaluated by 11 experts, generating item and scale‐level content validity indexes (I‐CVI and S‐CVI, respectively).
Alícia Tavares da Silva Gomes +2 more
wiley +1 more source
Clinical and Translational Medicine, Volume 12, Issue 4, April 2022., 2022 “In acute infection, combinations with only IFN‐γ were deleterious and those with IL‐2 were associated with a better course of acute infection. Additionally, mild patients had a more polyfunctional T response. In severe patients, there was increased antibody production inversely associated with the expression of combinations including IL‐2.
Alberto Pérez‐Gómez +25 more
wiley +1 more source
Clinical &Translational Immunology, Volume 11, Issue 7, 2022., 2022 In this study, we found that glycolipid‐peptide conjugate vaccines elicited greater peptide‐specific CD8+ T cell responses than peptide ± GM‐CSF and inhibited breast cancer metastasis to lung. Abstract Objectives Metastasis is the principal cause of breast cancer mortality.
Olivia K Burn +15 more
wiley +1 more source
People and Nature, Volume 3, Issue 2, Page 431-445, April 2021., 2021 Abstract Conservationists often assume that connection with and caring about nature's well‐being is strongly linked to ecological knowledge. Existing evidence on the link between ecological knowledge and psychological nature connection is mixed, geographically limited to countries in the Global North, and does not scrutinise potential differences in ...
Katarzyna Mikołajczak +7 more
wiley +1 more source