Results 11 to 20 of about 1,534 (172)

Motivations to donate blood and plasma: A scoping review of quantitative studies. [PDF]

Transfusion
Abstract Introduction Effective recruitment and retention of donors are essential for the supply of blood components and blood‐derived medicines. In many high‐income Western countries, there is an imbalance between demand and production of blood‐derived medicines.
Suárez-Artime P, Rey-Brandariz J, López García M, Casal Acción B, de Rivero de Aguilar Pensado A, Varela-Lema L.   +5 more
europepmc   +2 more sources

Distortion in the Communication of Nonsignificant Primary Outcomes: The Spin Strategy in Multiple Sclerosis Trials. [PDF]

Ann Neurol
Objective Spin refers to reporting strategies that highlight the benefits of an experimental treatment or divert attention from nonsignificant primary outcomes. We aimed to assess spin in randomized controlled trials (RCTs) on pharmaceutical efficacy in multiple sclerosis (MS) and explore associated factors.
Mascareñas-García M, Rivero-de-Aguilar A, Candal-Pedreira C, García G, Guerra-Tort C, Martín-Gisbert L, Rey-Brandariz J, Ríos MP, Casal-Acción B, Santiago-Pérez MI, Varela-Lema L.   +10 more
europepmc   +2 more sources

Intervenção de esportes modificados para melhorar metas de participação e competências de atividade em crianças deambuladoras com paralisia cerebral: um ensaio clínico randomizado. [PDF]

Dev Med Child Neurol
Intervenções de esportes modificados para crianças com Paralisia Cerebral: Resumo gráfico. Resumo Objetivo Avaliar a eficácia de uma intervenção de esportes modificados (Sports Stars Brasil) nos objetivos de participação em atividades físicas de lazer, desempenho e capacidade motora, funções corporais, níveis de atividade física, alfabetização física e
Sousa Junior RR, Clutterbuck GL, Guimaraes RF, Souza MG, Silva LC, Wright FV, Camargos ACR, Leite HR.   +7 more
europepmc   +2 more sources

Disinvestment in healthcare: An overview of HTA agencies and organizations activities at European level [PDF]

, 2018
Background: In an era of a growing economic pressure for all health systems, the interest for "disinvestment" in healthcare increased. In this context, evidence based approaches such as Health Technology Assessment (HTA) are needed both to invest and to ...
Calabrò, G. E., De Waure, C., Federici, A., La Torre, G., Ricciardi, W., Specchia, M. L., Villari, P.   +6 more
core   +4 more sources

The MegaPool Approach to Characterize Adaptive CD4+ and CD8+ T Cell Responses

Current Protocols, Volume 3, Issue 11, November 2023., 2023
Abstract Epitopes recognized by T cells are a collection of short peptide fragments derived from specific antigens or proteins. Immunological research to study T cell responses is hindered by the extreme degree of heterogeneity of epitope targets, which are usually derived from multiple antigens; within a given antigen, hundreds of different T cell ...
Ricardo da Silva Antunes, Daniela Weiskopf, John Sidney, Paul Rubiro, Bjoern Peters, Cecilia S. Lindestam Arlehamn, Alba Grifoni, Alessandro Sette   +7 more
wiley   +1 more source

Safety, pharmacokinetics and antiviral activity of ABI‐H2158, a hepatitis B virus core inhibitor: A randomized, placebo‐controlled phase 1 study

Journal of Viral Hepatitis, Volume 30, Issue 3, Page 209-222, March 2023., 2023
Abstract Treatment for chronic hepatitis B virus infection (cHBV) is mostly indefinite, with new finite‐duration therapies needed. We report safety, pharmacokinetics and antiviral activity of the investigational HBV core inhibitor ABI‐H2158. This Phase 1a/b study (NCT03714152) had three parts: Part A, participants received a single ascending oral dose ...
Kosh Agarwal, Jia Xu, Edward J. Gane, Tuan T. Nguyen, Yanhua Ding, Steven J. Knox, Katia Alves, Marc Evanchik, Katie Zomorodi, Julie Ma, Ran Yan, Qi Huang, Richard Colonno, Luisa M. Stamm, Tarek I. Hassanein, Dong Joon Kim, Young‐Suk Lim, Man‐Fung Yuen   +17 more
wiley   +1 more source

Eficacia del masaje perineal realizado durante el embarazo [PDF]

, 2015
Cartel presentado en la Segunda Conferencia Internacional de Comunicación en Salud, celebrada el 23 de octubre de 2015 en la Universidad Carlos III de MadridIntroducción: El momento del parto es clave para la mujer y a la vez una fuente de temores.
Martín Ortigosa, María Esther
core   +11 more sources

Detecting and reducing heterogeneity of error in acoustic classification

Methods in Ecology and Evolution, Volume 13, Issue 11, Page 2559-2571, November 2022., 2022
Abstract Passive acoustic monitoring can be an effective method for monitoring species, allowing the assembly of large audio datasets, removing logistical constraints in data collection and reducing anthropogenic monitoring disturbances. However, the analysis of large acoustic datasets is challenging and fully automated machine learning processes are ...
Oliver C. Metcalf, Jos Barlow, Yves Bas, Erika Berenguer, Christian Devenish, Filipe França, Stuart Marsden, Charlotte Smith, Alexander C. Lees   +8 more
wiley   +1 more source

Immunological memory to SARS‐CoV‐2 infection and COVID‐19 vaccines

Immunological Reviews, Volume 310, Issue 1, Page 27-46, September 2022., 2022
Abstract Immunological memory is the basis of protective immunity provided by vaccines and previous infections. Immunological memory can develop from multiple branches of the adaptive immune system, including CD4 T cells, CD8 T cells, B cells, and long‐lasting antibody responses.
Alessandro Sette, Shane Crotty
wiley   +1 more source

Development and validation of an instrument to assess Brazilians’ knowledge, perceptions, and behaviors toward salt and sodium

The Journal of Clinical Hypertension, Volume 24, Issue 5, Page 555-565, May 2022., 2022
Abstract This study aimed to develop and validate an instrument to assess Brazilian adults’ knowledge, perceptions, and behaviors (KPB) toward salt and sodium. Based on a PAHO/WHO questionnaire, a new instrument was developed and evaluated by 11 experts, generating item and scale‐level content validity indexes (I‐CVI and S‐CVI, respectively).
Alícia Tavares da Silva Gomes, Kamila Tiemann Gabe, Patricia Constante Jaime   +2 more
wiley   +1 more source