Investigating transcription factor dynamics in health and disease using FRAP
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Towards Attack and Defense Views to K-Anonymous Using Information Theory Approach
Ensuring multimedia content security is one of the main targets to solve multimedia information security problems and k-anonymous model is a classic and effective model to protect personal information when we publish multimedia data.
Cheng Liu +5 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Presenting social media information on mobile devices using multiple contexts
Purpose – Research has shown that when presenting large amounts of social media information on small devices, design should consider multiple contexts which include user preferences, time, location, environment and so on.
Tan, Esther Meng Yoke +1 more
core +1 more source
HOSPITAL COSTS AND INFORMATION THEORY CASE MIX INDEXES: RESULTS FOR QUEENSLAND
The use of information theory as a basis for the construction of scalar case mix indexes for hospitals is well established but to date no results arising from an application of these indexes to Australian hospitals have been published.
J.R.G. Butler
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Tracking down on 50-year History of Research about Information Management and Technology in Korea [PDF]
Dept. of Domestic Information Information Service Center Korea Institute of Science and Technology Information +1 more
core +1 more source
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