Results 231 to 240 of about 1,648,870 (357)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Variation in the Distribution Characteristics of <i>Nemopilema nomurai</i> in Relation to Marine Environmental Conditions. [PDF]

Biology (Basel)
Oh S, Kim KY, Youn SH, Lee K.
europepmc   +1 more source

Moderate deviations for non-linear functionals and empirical spectral density of moving average processes [PDF]

, 2004
Hacène Djellout, Arnaud Guillin, Liming Wu   +2 more
openalex   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Reasonable Planting Density and Chemical Regulation Can Improve the Plant Morphological Characteristics of Grain Maize, Enhance Lodging Resistance and Increase Yield in the Hexi Oasis. [PDF]

Plants (Basel)
Pan W, Deng H, Li F, Shi W, Wei J, Wang Q, Pan X, He W.   +7 more
europepmc   +1 more source

(a) Trends of annual average temperature from 2013 to 2023; (b) Trends of annual precipitation from 2013 to 2023; (c) Trends of NDVI from 2013 to 2023; (d) Trends of NPP from 2013 to 2023; (e) Trends in population density from 2013 to 2023; (f) Changes in land use types from 2013 to 2023.

Kai Liu (159026), Yunhong Song (637619), Shouying Du (592329), Hongye Xiao (21464059), Chaoqun Chen (354923), Jiang Xu (351121), Huimin Dai (2070307), Nana Fang (7832219)   +7 more
openalex   +1 more source

Mammographic density does not differ between unaffected BRCA1/2 mutation carriers and women at low-to-average risk of breast cancer

, 2010
Gretchen L. Gierach, Jennifer T. Loud, Catherine K. Chow, Sheila A. Prindiville, Jennifer Eng‐Wong, Peter W. Soballe, Claudia Giambartolomei, Phuong L. Mai, Claudia Galbo, Kathryn Nichols, Kathleen A. Calzone, Celine M. Vachon, Mitchell H. Gail, Mark H. Greene   +13 more
openalex   +2 more sources

Count2Density: Crowd Density Estimation without Location-level Annotations

Crowd density estimation is a well-known computer vision task aimed at estimating the density distribution of people in an image. The primary challenge in this domain is the reliance on fine-grained location-level annotations-i.e., points placed on top ...
Battiato, Sebastiano, Tsaftaris, Sotirios A, Litrico, Mattia, Chen, Feng, Pound, Michael, Giuffrida, Mario Valerio   +5 more
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source