Results 251 to 260 of about 8,764,462 (319)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

The Effect of Sport-Specific Brain Endurance Training on Performance in Elite Orienteering Athletes. [PDF]

Sports (Basel)
Buch K, Thomas R, Staiano W, Lønbro S.
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

ASTRA: a comprehensive resource of stress-induced transcriptional activity in human cell lines. [PDF]

Nucleic Acids Res
Tsifintaris M, Grigoriadis D, Sitmalidis M, Repanas P, Lazarashvili EK, Anastasiadi C, Kavakiotis I, Sandaltzopoulos R, Pavlopoulos GA, Giannakakis A.   +9 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Copy number and sequence variation in ribosomal DNA and the transposon, Pokey, in mutation accumulation lines of Daphnia obtusa. [PDF]

G3 (Bethesda)
Elguweidi A, Crease TJ.
europepmc   +1 more source

Bayesian Mixed Models Approach to Exploring Resilience: Impact of Stress on Subjective Health and Affects Over Time During the COVID-19 Pandemic. [PDF]

Int J Methods Psychiatr Res
Schepers M, Schmidtmann I, Schäfer SK, Yilmaz S, Baumkötter R, Hartmann A, Petersen J, Hettich-Damm N, Wild P, Zahn D, Wollschläger D.   +10 more
europepmc   +1 more source

Analysis of nationwide availability of negotiated drugs in China's National Reimbursement Drug List. [PDF]

Front Public Health
Zhang Y, Zhang W, Deng J, Liu Y, Sun L.
europepmc   +1 more source

Multi-Model Ensembles in Infectious Disease and Public Health: Methods, Interpretation, and Implementation in R. [PDF]

Stat Med
Shandross L, Howerton E, Contamin L, Hochheiser H, Krystalli A, Consortium of Infectious Disease Modeling Hubs, Reich NG, Ray EL.   +7 more
europepmc   +1 more source

Sexual behavior of young women with obesity indicated for bariatric treatment: A cross-sectional study. [PDF]

J Int Med Res
Zmolikova J, Bob P, Riethof N, Raboch J, Weiss P.   +4 more
europepmc   +1 more source