Results 141 to 150 of about 505,151 (317)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Determinants of Long-Term Growth: A Bayesian Averaging of Classical Estimates (BACE) Approach [PDF]
This paper examines the robustness of explanatory variables in cross-country economic growth regressions. It employs a novel approach, Bayesian Averaging of Classical Estimates (BACE), which constructs estimates as a weighted average of OLS estimates for
Gernot Doppelhofer +2 more
core
Periodic oscillations of the relativistic pendulum with friction
Electronic Journal of Differential Equations, 2017 We consider the existence and multiplicity of periodic oscillations for the forced pendulum model with relativistic effects by using the Poincare-Miranda theorem. Some detailed information about the bound for the period of forcing term is obtained. To
Qihuai Liu, Lukai Huang, Guirong Jian
doaj
Mathware & soft computing, 2001 This paper deals with the sets of strict conjectures and consequences of a given collection $P$ of premises. The set of Averaging Functions is introduced on lattices and some properties of these functions are shown. Averaging Functions allow to interpret "restricted consequences'' as averages of premises.
Trillas i Gay, Enric +2 more
openaire +3 more sources
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Default Priors and Predictive Performance in Bayesian Model Averaging, with Application to Growth Determinants [PDF]
Economic growth has been a showcase of model uncertainty, given the many competing theories and candidate regressors that have been proposed to explain growth.
Chris Papageogiou +2 more
core
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source