ISOLATION AND CHARACTERISTICS OF AVIAN NEPHROSIS-INDUCING INFECTIOUS BRONCHITIS VIRUS (CORONAVIRUS)
著者らは, 尿管系における尿酸塩様物質の貯留と, 腎の混濁腫張とを主徴とする雛の疾病を研究し, その腎乳剤を発育鶏卵に継代することによって, 病原と考えられるウイルス性因子を分離した. 雛に対するその病原性についてはすでに報告した. 本報告は, 鶏胎児腎初代培養細胞 (CEK) におけるこの分離ウイルスの増殖状況, 理化学的性状および形態について報告する. 本ウイルスの CEK における増殖は, 感染後8時間に培養液相現われ, 48~60時間でほとんど最高値6~7 log TCID50/mlに達した. 細胞変性効果 (CPE) の特徴は, 原形質の空胞化, 感染細胞の球状化, そして円形化細胞の管壁からの脱落である. 封入体は認められなかった.
K, Hirai, S, Shimakura
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Heterogeneity of gene expression of the hemagglutinin-esterase (HE) protein of murine coronaviruses. [PDF]
The hemagglutinin-esterase (HE) membrane glycoprotein is present only in some members of the coronavirus family, including some strains of mouse hepatitis virus (MHV). In the JHM strain of MHV, expression of the HE gene is variable and corresponds to the
Banner, LR, Lai, MM, Yokomori, K
core
ABSTRACT Protein–receptor interactions play a critical role in viral entry and pathogenesis. While ACE2 is the primary receptor for SARS‐CoV, the role of DPP4 as potential coreceptor remains underexplored. This study investigates the binding mechanisms and dissociation dynamics of the SARS‐CoV/DPP4, SARS‐CoV/ACE2 and MERS‐CoV/DPP4 complexes using ...
Patrícia Pereira Duzi Carvalho +1 more
wiley +1 more source
Avian coronavirus strain Italy 02, recently identified in Morocco, has caused substantial economic losses in the poultry sector. This study evaluated the efficacy of the live attenuated Mass-type H120 vaccine against this strain in broiler chickens ...
Khadija Khataby +5 more
doaj +1 more source
Discovery and Characterization of Novel RNA Viruses in Aquatic North American Wild Birds
Wild birds are recognized viral reservoirs but our understanding about avian viral diversity is limited. We describe here three novel RNA viruses that we identified in oropharyngeal/cloacal swabs collected from wild birds.
Marta Canuti +5 more
doaj +1 more source
In vivo and in vitro models of demyelinating diseases. V. Comparison of the assembly of mouse hepatitis virus, strain JHM, in two murine cell lines. [PDF]
The developmental sequence of a neurotropic strain (JHM) of mouse hepatitis virus was examined by transmission electron microscopy and immunocytology. The nucleoprotein core of this coronavirus, which contains RNA of positive polarity and is helical in ...
Buchmeier, MJ +4 more
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Generation of a Defective RNA of Avian Coronavirus Infectious Bronchitis Virus (IBV) [PDF]
The Beaudette strain of IBV was passaged 16 times in chick kidney (CK) cells. Total cellular RNA was analyzed by Northern hybridization and was probed with 32P-labeled cDNA probes corresponding to the first 2 kb of the 5' end of the genome, but excluding the leader, and to the last 1.8 kb of the 3' end of the genome.
Z, Penzes +5 more
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The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +206 more
wiley +1 more source
Infectious bronchitis virus infections of chickens in Belgium : an epidemiological survey [PDF]
Between April 2012 and July 2015, cloacal and/or tracheal swab samples were collected from four hundred and twenty-four Belgian chicken broiler, breeder and layer flocks.
Currie, R +3 more
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Science for Pandemic Preparedness: A Precautionary Framework
ABSTRACT In the early weeks of the pandemic year 2020, health agencies were slow to warn of the potential for a global health emergency while scientists waited for ‘sufficient’ evidence of human‐to‐human transmission of the new coronavirus. There were further delays and confusion in issuing guidance because of uncertainty about the most important ...
David Kriebel +2 more
wiley +1 more source

