Results 111 to 120 of about 143,027 (290)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Modern GeográfiaMárton Veress was born on February 7, 1946 in Szombathely, Hungary. He graduated from the József Attila University as a teacher of Biology and Geography. He became the doctor of Hungarian Academy of Sciences in 2004.
Pusztai-Eredics, Alexandra +1 more
doaj +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
GG and the City: What Canada’s Major Translation Award Reveals about Its Metropolises
Text MattersIn this article I consider the predominance of metropolises in the Canadian publishing sector through the lens of award-winning translations. My research is based on a database of information on Canadian literary prizes (gathered through reports and ...
Myriam Legault-Beauregard
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
MONETARY AND NON-MONETARY INCENTIVES TO BOOST TAX PAYMENT A CONTROLLED EXPERIMENT
Visión de Futuro, 2012 After centuries in which control and punishment formed the basis of policies designed to combat tax evasion, the results in many world economies are far from expected.
Victoria, Giarrizzo
doaj
Accelerating innovation with prize rewards: History and typology of technology prizes and a new contest design for innovation in African agriculture [PDF]
"This paper describes how governments and philanthropic donors could drive innovation through a new kind of technology contest. We begin by reviewing the history of technology prizes, which operate alongside private intellectual property rights and ...
Delbecq, Benoit, Masters, William A.
core
Spartan Daily, May 20, 1957 [PDF]
, 1957 Volume 44, Issue 129https://scholarworks.sjsu.edu/spartandaily/12486/thumbnail ...
San Jose State University, School of Journalism and Mass Communications
core +1 more source