Results 31 to 40 of about 5,359 (250)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
The spirit of competition: to win or not to win. [PDF]
PLoS Computational Biology, 2013 A competition is a contest between individuals or groups. The gain is often an award or recognition, which serves as a catalyst to motivate individuals to put forth their very best.
Teresa Szczepinska +2 more
doaj +1 more source
Rola reportażu i jego miejsce na polskim rynku książki w pierwszych dekadach XXI wieku
Zagadnienia Rodzajów Literackich, 2022 Literary reportage has been one of the most popular genres in Poland in recent years. Works written by Polish and foreign reporters are published by the main publishing houses in the country.
Kamila Augustyn
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Romanian Literature in British Translation Prizes
Translation Studies: Theory and PracticeAs a component of a larger project on translation awards, this article examines the presence of literary works originally written in Romanian in recent iterations of four prominent British prizes for literary translation: the EBRD Literature Prize, the ...
Antony Hoyte-West
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Post-Millennium Nobel Literature Prizes in the Context of Global Literary Trends
İstanbul Üniversitesi Edebiyat Fakültesi Türk Dili ve Edebiyatı Dergisi, 2021 Globalization has intensely affected the leading art of literature that has, for centuries, deployed languages to discharge a pivotal role in the construction of national cultures.
Fethi Demir, Nahide Ece Süslü
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Zhongguo youzhi中国粮油学会科学技术奖（简称“粮油科技奖”）是我国粮食行业唯一的科技奖励。为促进粮油科技奖持续健康发展，更好地发挥粮油科技奖的激励导向作用，简要回顾梳理了近二十年（2005—2023年）来粮油科技奖概况，总结分析了粮油科技奖的特点和实效，提出了奖励工作面临的挑战与建议。2005—2023年，共受理项目1 055项，获奖项目609项，其中特等奖6项，一等奖96项，二等奖212项，三等奖295项。粮油科技奖励工作具有奖励机制不断完善，注重发挥示范引领作用，扎实推进科技兴粮兴储，提高企业自主创新能力等特点 ...
杨晓静， 陈志宁 YANG Xiaojing, CHEN Zhining
doaj +1 more source