Results 41 to 50 of about 93,967 (312)

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

CFD analysis and optimization of axial flow fans

International Journal for Simulation and Multidisciplinary Design Optimization
The axial fan plays a vital role in the safe production of the mine, and in this paper, a mine axial flow ventilator is designed through numerical simulation to meet the demand of air exchange inside and outside of the mine, so as to maintain the oxygen ...
Liu Renhui, Xu Shubo, Sun Kangwei, Ju Xiaoyu, Zhang Weihai, Wang Wenming, Ma Xiquan, Pan Yuefei, Li Jianing, Ren Guocheng   +9 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

The effect of the inlet chamber and diffuser on the reverse aerodynamic performance of an axial flow fan

Acta Polytechnica
Flow reversal in axial fans is usually carried out by changing the direction of rotation of the fan and rotating the stator vanes. The total pressure losses of selected inlet fan chambers were determined using CFD data for the normal and reverse flow ...
Václav Cyrus, Jan Cyrus
doaj   +1 more source

Experimental Study of the Leakage Flow in an Axial-Flow Fan at Variable Loading

International Journal of Turbomachinery, Propulsion and Power, 2021
The present paper reports a 2D-PIV (particle image velocimetry) study of the effect of the operating point on the leakage flow in a low-speed ring fan.
Edward Canepa, Andrea Cattanei, Mehrdad Moradi, Alessandro Nilberto   +3 more
doaj   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Characterization of Defect Distribution in an Additively Manufactured AlSi10Mg as a Function of Processing Parameters and Correlations with Extreme Value Statistics

Advanced Engineering Materials, EarlyView.
Predicting extreme defects in additive manufacturing remains a key challenge limiting its structural reliability. This study proposes a statistical framework that integrates Extreme Value Theory with advanced process indicators to explore defect–process relationships and improve the estimation of critical defect sizes. The approach provides a basis for
Muhammad Muteeb Butt, Varma Kvvssn, Hossein Laieghi, Zia Uddin, Peyman Ansari, E. Kıvanç Sadak, Can Barış Toprak, Hüseyin Kızıl, Enrico Salvati   +8 more
wiley   +1 more source

Optimal Design of Axial Flow Fan Structure Parameters based on Flow Field Analysis and Aerodynamic Experiment of Rectangular Duct

Zhileng xuebao, 2019
In this study, a flow structural model in a rectangular channel with an axial flow fan is established and analyzed through numerical simulation and experiments to get the influence of two design parameters, i.e., axial length of the deflector and tip ...
Huang Haihong, Lu Yuexing, Ke Qingdi, L
doaj  

On‐Demand Activation of Thin Alginate Shell Encapsulated Volatile Liquid for Untethered Pneumatic Soft Actuation

Advanced Engineering Materials, EarlyView.
Phase‐changing liquids enable untethered pneumatic actuation in soft robotics but suffer from volatility and storage challenges. This work reports a simple method to encapsulate Novec 7000 within micron‐thin alginate shells via in situ injection and ionic crosslinking.
Rayan A. M. Basodan, Jack Keddie, Byoungyoul Park, Hyun‐Joong Chung   +3 more
wiley   +1 more source