Results 41 to 50 of about 17,797 (259)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Design and Analysis of ?79 mm Solid-Liquid Axial Flow Pump Blade

Shiyou jixie, 2020
To speed up the implementation of the national key R&D project"technology research and application of dual gradient drilling system",the φ79 mm axial flow pump used for the special conditions of deepwater gas hydrate mining is designed.
Zhang Xiaodong, Hao Renjie, Gong Yan, Lin Meng   +3 more
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Design Method for Low Specific Speed Axial Flow Pump for High-Speed Undersea Vehicles

水下无人系统学报
For the axial flow pumps water-jet propulsion system of undersea vehicles, the high specific speed axial flow pump designed by the lift method fails to work under shallow water and high-speed conditions at present.
Ziruo ZHANG, Kai LUO, Kan QIN
doaj   +1 more source

Numerical Simulation and Experiment of the Effects of Blade Angle Deviation on the Hydraulic Characteristics and Pressure Pulsation of an Axial-Flow Pump

Shock and Vibration, 2021
Inadequate blade angle adjustment or manufacturing errors will cause inconsistencies in the blade angle of an axial-flow pump. In this study, the hydrodynamic characteristics of an axial-flow pump with inconsistent blade angle are investigated by ...
Lijian Shi, Jun Zhu, Yao Yuan, Fangping Tang, Penglan Huang, Wenpeng Zhang, Haiyu Liu, Xiaowen Zhang   +7 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Numerical analysis of pressure fluctuation characteristics of axial flow pump device of edge pump unit in multi-unit pumping station

AIP Advances
Asymmetric layout gate station projects are prevalent in gate station engineering. When multiple pump units operate within such projects, the inflow patterns of the pump devices at different stations exhibit significant variations.
Sihai Li, Yi Luan, Yongbing Xu, Xizhu Liu, Fan Yang, Guiying Xu   +5 more
doaj   +1 more source

Influence of guide vanes on the flow fields and performance of axial pump under unsteady flow conditions: Numerical study

Journal of Mechanical Engineering and Sciences, 2020
Influence of different guide vanes on structural of flow field and axial pump performance under unsteady flow is carried out using numerical method. A three-dimensional axial flow pump model is numerically simulated using computational fluid dynamics ...
Ahmed Ramadhan Al-Obaidi
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Analysis of internal flow characteristics and structure optimization of vertical submersible axial flow pump device

Advances in Mechanical Engineering, 2022
In order to investigate the internal flow characteristics and hydraulic stability of vertical submersible pump station in forward and reverse operation, the steady and unsteady three-dimensional numerical simulation of vertical submersible axial-flow ...
Fan Yang, Zhikang Lin, Jindong Li, Ahmed Nasr, Weiguo Cong, Chao Li   +5 more
doaj   +1 more source