Results 111 to 120 of about 2,366,371 (335)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Axial length development in children.
International Journal of Ophthalmology, 2019 AIM To study ocular axial lengths in pediatric subjects without intraocular pathology. METHODS An Institutional Review Board-approved consecutive retrospective chart review of axial lengths measured in pediatric subjects who underwent examination under
A. Bach +4 more
semanticscholar +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Structural Performance of Columns with Glass Fiber-Reinforced Polymer Bars Under Axial Compression
FibersCorrosion continues to be a major challenge affecting the service life, safety and durability of steel-reinforced concrete (RC) structures. The deterioration of steel not only reduces structural capacity but also increases long-term maintenance costs. To
Trupti Amit Kinjawadekar +2 more
doaj +1 more source
The Mechanical Impact of Aerodynamic Stall on Tunnel Ventilation Fans
International Journal of Rotating Machinery, 2012 This paper describes work aimed at establishing the ability of a tunnel ventilation fan to operate without risk of mechanical failure in the event of aerodynamic stall.
A. G. Sheard, A. Corsini
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Beyond Dopamine: GABA, Glutamate, and the Axial Symptoms of Parkinson Disease
Frontiers in Neurology, 2018 Introduction: The axial symptoms of Parkinson disease (PD) include difficulties with balance, posture, speech, swallowing, and locomotion with freezing of gait, as well as axial rigidity. These axial symptoms impact negatively on quality of life for many
R. O. O'Gorman Tuura +2 more
semanticscholar +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Revista Argentina de ReumatologíaLa espondiloartritis axial (EspAax) es una enfermedad crónica inflamatoria que incluye a la espondiloartritis radiográfica (EspAax-r) (anteriormente conocida como espondilitis anquilosante [EA]) y a la espondiloartritis axial no radiográfica (EspAax-nr)
María Victoria Martire +23 more
doaj +1 more source