Results 51 to 60 of about 3,499,148 (310)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Study on Creep Compression Characteristics of Pressure-Bearing Graded Crushed Rock

Buildings
To study the creep compression characteristics and evolution mechanism of pressure-bearing graded crushed rock under constant load. Creep compression tests of crushed rock were conducted using the self-developed confined compression test system under ...
Yu Tian, Mei Zhi, Jie Zhou, Pengfei Ji, Shitong Peng   +4 more
doaj   +1 more source

Influence of design parameters on the global performances of low-speed counter-rotating axial-flow fans [PDF]

, 2014
The present work aims at experimentally investigating the effects of some parameters on the performances of a counter-rotating stage, and on the instationary flow between the rotors.
BAKIR, Farid, RAVELET, Florent, Juan Wang, WANG, Juan, Farid Bakir, Florent Ravelet   +5 more
core   +1 more source

Modelling hollow pultruded FRP profiles under axial compression: Local buckling and progressive failure [PDF]

, 2021
Pultruded Fibre-Reinforced Polymer (PFRP) profiles are widely used as structural elements in many civil infrastructure applications. However, the anisotropic elasticity and the application-driven slenderness make these profiles prone to local buckling ...
Aravinthan, Thiru, Shelley, Tristan, Kemp, Michael, Zeng, Xuesen, Alajarmeh, Omar, Schubel, Peter, Alhawamdeh, Mohammad   +6 more
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Seismic Performance of Precast Short-Limb Shear Wall with the Bundled Connection at Different Axial Compression Ratios

Materials, 2023
In order to investigate the seismic performance of a precast shear wall with a new bundled connection under a high axial compressive ratio, three full-scale precast short-limb shear walls and one full-scale cast-in-place short-limb shear wall were manufactured and loaded under cycling loading.
Gang Chen, Zihao Yu, Xiaohui Zhang, Hailong Yang, Qian Zhang, Jian Feng, Jianguo Cai   +6 more
openaire   +2 more sources

Behaviour and design of composite beams subjected to negative bending and compression [PDF]

, 2012
This paper investigates the behaviour of steel–concrete composite beams subjected to the combined effectsof negative bending and axial compression. For this study, six full-scale tests were conducted on compositebeams subjected to negative moment while ...
Uy, Brian (R9735), Vasdravellis, George; id_orcid, Kirkland, Brenadan, Uy, Brian, Vasdravellis, George (R16696), Tan, Ee Loon (R14425), Tan, Ee Loon, Kirkland, Brendan (S24876)   +7 more
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Finite element analysis of high-rise prefabricated shear walls with discontinuous rebars

Scientific Reports
The seismic performance of vertical reinforcement discontinuous splice prefabricated shear walls (SGBL prefabricated shear walls) in high-rise buildings is investigated in this study.
Zhiqi Li, Jun Peng, Hairen Wang, Wenyi Xia, Jianyin Lei, Jiaxin He, Yunhui Chen, Yaoyao Liu, Jiahui Zhang, Xiyong Sun, Haiping Xie   +10 more
doaj   +1 more source

Nonlinear Finite-Element Analysis of RC Bridge Columns under Torsion with and without Axial Compression [PDF]

, 2016
Finite-element (FE) modeling of RC structures under combined loading has received considerable attention in recent years. However, the combination of torsion and axial compression has been rarely studied in spite of its frequent occurrence in bridge ...
S, Suriya Prakash, Mondal, T G
core   +1 more source