Results 41 to 50 of about 1,857,853 (240)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Measurement of Axial Dispersion Coefficient of the Continuous Phase in a Pulsed Disc and Doughnut Column Using Dispersion Model with Radiotracer Technique [PDF]

مجله علوم و فنون هسته‌ای, 2016
High efficiency and low required area for the pulsed columns are interesting and useful especially in nuclear industries in spite of exposure and radiation protection requirements.
M Tabasi, Y Yaghoubi, M Outokesh, M Torab- Mostaedi   +3 more
doaj  

Axial dispersion model in predictive mass transfer correlation for random pulsed packed column [PDF]

Chemical Industry and Chemical Engineering Quarterly, 2015
The continuous phase volumetric overall mass transfer coefficient in a ceramic intalox saddle pulsed packed extraction column using axial dispersion model was studied for two different liquid-liquid systems containing water/acetone/toluene and ...
Teflanab R., Ghoreishi S.M., Safdari J., Torab-Mostaedi M.   +3 more
doaj   +1 more source

Thermal Modelling of the Ventilation and Cooling inside Axial Flux Permanent Magnet Generators [PDF]

, 2010
Axial flux permanent magnet generators are of particular interest for power generation in harsh and confined conditions. Due to their compactness and high power density, the ventilation and cooling inside axial flux permanent magnet generators have ...
LIM, CHIN,HONG, Lim, Chin Hong
core  

Oscillatory flow and axial dispersion in packed beds of spheres

, 2005
The effect of oscillations in the bulk flow on the axial dispersion coefficient in packed beds of spherical particles has been studied using the imperfect pulse tracer method with two probes located within the bed.
Lau, A, Brinkmann, T, Field, Robert, Crittenden, BD   +3 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Refractive index characteristics of edible oils based on spectrometry and effects of oil dispersion on OCT

Journal of Innovative Optical Health Sciences, 2021
It is necessary to investigate the wavelength-dependent variation rules of the refractive index of edible oils so as to explore the specificity of the dispersion in light propagation, imaging, and interference processes among different types of edible ...
ShiJun Xu, XiaoKang Li
doaj   +1 more source