Results 81 to 90 of about 9,885,022 (252)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Classical and numerical approaches to determining V-section band clamp axial stiffness [PDF]

, 2014
V-band clamp joints are used in a wide range of applications to connect circular flanges, for ducts, pipes and the turbocharger housing. Previous studies and research on V-bands are either purely empirical or analytical with limited applicability on the ...
Khodabakhshi, Goodarz, Barrans, Simon, Muller, Matthias, Khodabakhshi Goodarz, Barrans, Simon M., Muller Matthias, Barrans Simon M.   +6 more
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Investigating the Interhemisphere 14C Offset in the 1st Millennium AD and Assessment of Laboratory Bias and Calibration Errors [PDF]

, 2009
Past measurements of the radiocarbon interhemispheric offset have been restricted to relatively young samples because of a lack of older dendrochronologically secure Southern Hemisphere tree-ring chronologies. The Southern Hemisphere calibration data set
Palmer, Jonathan G., Hogg, A., Boswijk, G., Reimer, Paula J., Hogg, Alan, Hogg, Alan G., Palmer, Jonathan, Reimer, Paula, Palmer, J., Boswijk, Gretel, Reimer, Paula; id_orcid, Brown, David   +11 more
core   +1 more source

Application and analysis of Cr-coated GdN-CBA to i-SMR core with two control rod patterns for load-following operations

Nuclear Engineering and Technology
A new burnable absorber called GdN-CBA with Cr-coating is applied to the i-SMR (Innovative Small Modular Reactor) for boron-free operation. The burnable absorber considered in this study employs a gadolinium nitride coating burnable absorber with a 20 μm
Woo Jin Lee, Sung Hyun Cho, Seung Hyeon Choi, Ser Gi Hong   +3 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

CFD Leakage Predictions of Unworn and Worn Labyrinth Seals With and Without Tooth Axial Offset

, 2017
The objective of this study is to develop a Computational Fluid Dynamics (CFD) based methodology for analyzing and predicting leakage of worn or rub-intended labyrinth seals during operation.
Alexander Mirzamoghadam, Hasham H. Chougule   +1 more
core   +1 more source

Investigation of Offset Recovery Algorithms for High-Performance Bluetooth Receivers

, 2005
Research has shown that significant degradation in performance can occur even when operating within the limits for carrier frequency and modulation index offsets permitted by the Bluetooth standard.
Tibenderana, C, Weiss, S, Tibenderana, C., Weiss, S.   +3 more
core   +1 more source

Primary osteoarthritis of the shoulder: are there differences in scapular morphology, orientation, and rotator cuff action lines between patients and healthy controls?

JSES International
Background: There is currently no in depth description of glenoid vault morphology, the rotator cuff action lines, and scapulothoracic orientation in patients with shoulder osteoarthritis (OA).
Doruk Akgün, MD, Alp Paksoy, MD, Paul Siegert, MD, Isabella Weiß, MD, Philipp Moroder, MD   +4 more
doaj   +1 more source