Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Effect of damping groove on flow dynamics and vibration characteristics of axial piston pump
This paper presents pressure, flow and vibration characteristics of an axial piston pump valve plate with damping grooves. For flow ripple and vibration of the pump reduction, an improved compressible fluid model of axial-piston pump with damping groove ...
Tang Hesheng +3 more
doaj +1 more source
Design of a new-concept conical positive displacement slurry pump for continuous de-clogging [PDF]
Slurry pumps are extensively used in the construction industry while positive displacement screw pumps are used in most mobile concrete pump applications. The aggregate size is known to significantly affect pump performance in terms of clogging.
Vasileiou G. +4 more
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Influence of Guide Vane Slope on Axial-Flow Hydraulic Performance and Internal Flow Characteristics
To comprehensively study the influence of the guide vane inlet slope on the axial-flow pump, eight groups of axial-flow pumps with different guide vane inlet slopes are designed and studied in this paper.
Yue Li +3 more
doaj +1 more source
A method for calculating the effects of design errors and measurement errors on pump performance [PDF]
Technique has been developed for calculating effects of design errors and measurement errors on pump performance. Error equations and charts are utilized to relate amount of error in given performance parameter to amount of error in given design or ...
Anderson, D. A.
core +1 more source
Fluid-induced Rotordynamic Forces and Instabilities [PDF]
In the late 1970s, the authors began a collaboration with our colleague Tom Caughey that helped define a new set of fluid-structure interaction phenomena in turbomachines, namely fluid-induced rotordynamic forces and instabilities. That collaboration and
Acosta, Allan J. +1 more
core +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
Pressure probe compensates for dimensional tolerance variations [PDF]
Flexible, compressible spring-loaded pressure probe measures the static pressure between the rotor stages on an axial-flow fuel pump. This probe is used in installation where a drilled static pressure tap or a rigid impulse tube cannot be used.
Birner, R. A.
core +1 more source
A numerical investigation on the vortex formation and flow separation of the oscillatory flow in jet pumps [PDF]
A two-dimensional computational fluid dynamics model is used to predict the oscillatory flow through a tapered cylindrical tube section (jet pump) placed in a larger outer tube.
ANSYS +8 more
core +3 more sources

