Results 31 to 40 of about 164,015 (303)
Reciprocal control of viral infection and phosphoinositide dynamics
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
The methods employed to calculate the axial bearing capacity of a helical pile depends on the shear failure model around the pile, which is also influenced by the spacing and diameter of the helical plates.
Ignatius Tommy Pratama +2 more
doaj +1 more source
The QCD Chiral Condensate from the Lattice [PDF]
We determine the chiral condensate from simulations of quenched lattice QCD with Wilson fermions. Our measurements have been obtained with high statistics at three values of the gauge coupling, corresponding to UV cutoffs in the range 2 - 4 GeV.
A. Vladikas +73 more
core +3 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Well spacing and reinjection rate are two critical parameters controlling the efficiency and sustainability of hot dry rock geothermal development. Taking the Yangbajing geothermal field in Tibet as the geological setting, permeability experiments were ...
Tengyu Tian +3 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
This study evaluates the seismic behavior of reinforced concrete (RC) short columns with a high axial compression ratio under oblique earthquake conditions.
Chunyang Liu +4 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Cone mosaic in eyes with varied axial length using adaptive optics scanning laser ophthalmoscopy
Background: Abnormalities in cone photoreceptor topography are closely associated with the development of various ocular diseases, including axial myopia.
Wen-Da Zhou +11 more
doaj +1 more source
Is the ground state of Yang-Mills theory Coulombic? [PDF]
We study trial states modelling the heavy quark-antiquark ground state in SU(2) Yang-Mills theory. A state describing the flux tube between quarks as a thin string of glue is found to be a poor description of the continuum ground state; the infinitesimal
A. Ilderton +9 more
core +3 more sources

