Results 61 to 70 of about 3,717 (247)

Paracrine Orchestration of Tumor Microenvironment Remodeling Induced by GLO1 Potentiates Lymph Node Metastasis in Breast Cancer

Advanced Science, EarlyView.
Single‐cell RNA sequencing of lymph node (LN) samples is performed, and a comprehensive landscape of the entire ecosystem is generated. Paracrine orchestration of TME remodeling induced by GLO1 potentiates LN metastasis in breast cancer. This study offers novel perspectives on the microenvironment remodeling of breast cancer LN metastases, suggesting ...
Jindong Xie, Wenjian Liu, Xinpei Deng, Huan Wang, Xueqi Ou, Xin An, Min‐Yi Situ, Anli Yang, Chuan Peng, Rongfang He, Yi Xie, Hailin Tang, Yuman Chen, Jie‐Ying Liang, Ruonan Shao, Weikai Xiao, Shaoquan Zheng   +16 more
wiley   +1 more source

Responsive ROS‐Augmented Prodrug Hybridization Nanoassemblies for Multidimensionally Synergitic Treatment of Hepatocellular Carcinoma in Cascade Assaults

Advanced Science, EarlyView.
This study proposes a novel HCC therapy using CA‐4S2@ES‐Cu nanomedicines to amplify cuproptosis, enhancing chemotherapy and immunotherapy. CA‐4 and ES‐Cu synergistically inhibit tumor growth, induce immune responses, and reverse the immunosuppressive microenvironment, offering an effective multidimensional therapeutic strategy for HCC treatment ...
Yingjie Zeng, Yuening Cao, Senmiao Ren, Chaozheng Zhang, Jianan Liu, Ke Liu, Yan Wang, Hongyu Chen, Fengjiao Zhou, Xiuli Yang, Xian Ge, Tingting Zhang, Tianbao Wang, Yao He, Defang Li, Chuantao Zhang, Jun Lu   +16 more
wiley   +1 more source

Management of the Axilla in the Era of Breast Cancer Heterogeneity

Frontiers in Oncology, 2018
Systemic cancer therapies take into account breast cancer (BC) heterogeneity by targeting pathways specifically involved in some BC subtypes. On the other hand, BC intrinsic radiosensitivity is poorly understood and studied.
Maïlys de Meric de Bellefon, Claire Lemanski, Angélique Ducteil, Pascal Fenoglietto, David Azria, David Azria, David Azria, Celine Bourgier, Celine Bourgier, Celine Bourgier   +9 more
doaj   +1 more source

PP1A Modulates the Efficacy of Lenvatinib Plus ICIs Therapy by Inhibiting Ferroptosis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
PP1A dephosphorylates Keap1 at the S104 site, stabilizing and promoting the nuclear translocation of Nrf2, which upregulates the expression of antioxidant genes and PD‐L1. This leads to suppressed ferroptosis and enhanced immune evasion, thereby improving the efficacy of TKI and ICI combination therapy.
Jitong Zhou, Meng Gao, Shikun Zhang, Wing‐Wa Guo, Wenzhi He, Minghe Zhang, Xi Chen, Cairang Dongzhi, Xiaomian Li, Yufeng Yuan, Weijie Ma   +10 more
wiley   +1 more source

Benign phyllodes tumor of axillary tail USG and elastography evaluation with histopathological correlation

Journal of Medical Ultrasound
The axillary tail, also known as spencer's tail or axillary process, is a continuation of tissue from the upper lateral quadrant of the breast that travels into the axilla through a foramen of Langer in the deep fascia. Axillary inflammation or lump is a
Gopidi Sai Nidhi Reddy, Suresh Vasant Phatak, Prashanthi Ganta, Nagendra Vadlamudi   +3 more
doaj   +1 more source

Genetic Regulation of Alternative Polyadenylation Provides Novel Insights into Molecular Mechanisms Underlying Non‐small Cell Lung Cancer

Advanced Science, EarlyView.
Compared with the non‐risk G allele of rs9606, the risk T allele of rs9606 decreases the binding affinity of NUDT21 for LYRM4, triggering 3'UTR shortening that stabilizes LYRM4 mRNA and elevates its expression. Increased LYRM4 expression promoted malignant phenotypes of non‐small cell lung cancer (NSCLC) cells through modulating ferroptosis, supporting
Meng Jin, Yongbiao Huang, Bin Li, Yuan Wang, Yan Li, Zhirui Chen, Zhe Tang, Chaofan Liu, Lei Zhang, Xianglin Yuan, Jianbo Tian, Bo Liu   +11 more
wiley   +1 more source

Clinicopathological Correlation of Axillary Masses – Importance of Fine Needle Aspiration Cytology as a Diagnostic Modality

Journal of Medical Sciences and Health, 2017
Introduction: The axilla, a triangular area located between the upper arm and thorax, contains blood vessels, nerves, lymph nodes, and fat. The most common palpable axillary masses are usually lymph nodes.
Aniruna Dey, Riti T K Sinha
doaj  

Functional effects of preserving the intercostobrachial nerve and the lateral thoracic vein during axillary dissection in breast cancer conservative surgery [PDF]

Vojnosanitetski Pregled, 2007
Background/Aim. Conventional axillary dissection in breast cancer surgery implicates the section of the neurovascular elements passing through the dissected tissue: the intercostobrachial nerve (ICBN) and lateral thoracic vein (LTV).
Ivanović Nebojša, Granić Miroslav, Ranđelović Tomislav, Bilanović Dragoljub, Đukanović Blagoje, Ristić Nataša, Babić Darko   +6 more
doaj   +1 more source

Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis

Advanced Science, EarlyView.
Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu, Shengyu Jin, Xin Fu, Chong Xie, Yi Chen, Liangtang Chang, Yongheng Fan, Donghua He, Xiaoqi Hong, Xi Shen, Xiaoli Zheng, Qiyue Wang, Dao Shi, Fangyuan Li, Daishun Ling, Yangtai Guan, Neng Gong, Xiaoping Tong   +17 more
wiley   +1 more source

Sclerotic Fibroma Presenting as an Axillary Mass: A Case Report with Imaging Features

대한영상의학회지, 2021
Sclerotic fibroma or storiform collagenoma is a rare benign neoplasm that predominantly affects the skin layer of the head, neck, or limbs. Less frequently, it occurs in non-dermal spaces such as the subcutaneous layer.
Tae-Eun Kim, Ji Young Lee
doaj   +1 more source