Results 71 to 80 of about 12,298,173 (375)

Integrated Population Pharmacokinetic, Pharmacodynamic, and Safety Analyses to Inform Dosage Selection in the Clinical Development of the ATR Inhibitor Tuvusertib

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
We present model‐informed selection of the recommended dose for expansion (RDE) of investigational oral ATR inhibitor tuvusertib, by integrating clinical pharmacokinetics (PK), pharmacodynamics (PD), and safety data from DDRiver Solid Tumors 301 trial Part A1 (NCT04170153).
Jatinder Kaur Mukker   +20 more
wiley   +1 more source

Manufacturing system design based on axiomatic design: Case of assembly line

open access: yesJournal of Industrial Engineering and Management, 2017
Purpose:  In this paper, a combined Production Line Design (PLD) process which includes many design aspects  is presented, developped and validated.
Triki Hager   +2 more
doaj   +1 more source

Improving Patient Flow Through Axiomatic Design of Hospital Emergency Departments [PDF]

open access: yes, 2009
Organised by: Cranfield UniversityIn response to crowding in hospital emergency departments (ED), efforts have been made to increase patient flow through the Fast Track (FT).
Kim, S-G., Peck, J.
core  

On the Applicability of the Advocacy Coalition Framework for Analyzing EU Policy Processes

open access: yesEuropean Policy Analysis, EarlyView.
ABSTRACT Initially developed for the US context, the Advocacy Coalition Framework (ACF) is increasingly used to analyze policy processes in the EU. But policymaking in EU differs from the US context, why the applicability of ACF in the EU context should be scrutinized.
Fredrik von Malmborg
wiley   +1 more source

From decision patience to process patience: A decision–process integration of the choice to wait and the experience of waiting

open access: yesJournal of Consumer Psychology, EarlyView.
Abstract Consumer impatience has long been examined through the lens of intertemporal choice, where patience is inferred from decisions to accept delayed rewards. Yet, this conceptualization captures only the choice to wait, not the experience of waiting.
Selin A. Malkoc
wiley   +1 more source

Theorem proving support in programming language semantics [PDF]

open access: yes, 2007
We describe several views of the semantics of a simple programming language as formal documents in the calculus of inductive constructions that can be verified by the Coq proof system.
Bertot, Yves
core   +3 more sources

Gender Differences in Multidimensional Poverty in Low‐ and Middle‐Income Countries

open access: yesJournal of International Development, EarlyView.
ABSTRACT Despite the growing demand for gender‐disaggregated statistics on poverty, there is hardly any cross‐country evidence of gender disparities in poverty. The paper contributes to filling this gap, by using two novel individual‐level indices of multidimensional poverty.
Francesco Burchi, Daniele Malerba
wiley   +1 more source

Research on product innovation design of modularization based on theory of TRIZ and axiomatic design

open access: yesAdvances in Mechanical Engineering, 2018
Modular design can shorten the product development cycle and enhance the product research and development capability of enterprises. To better solve the problem of module interface coupling after module partition, the present modular product design ...
Zhong-hang Bai   +3 more
doaj   +1 more source

Axiomatic Deisgn of Manufacturing Systems [PDF]

open access: yes, 1996
This paper introduces the use of axiomatic design in the design of manufacturing systems. The two primary functional requirements of any manufacturing system are developed.
Cochran, David, Reynal, Vicente
core  

Bounded Sustainable Entrepreneurship: Uncertainty, Perceptions, and Tensions

open access: yesStrategic Change, EarlyView.
ABSTRACT Entrepreneurs experience subjective perceptions of uncertainty and other barriers as they attempt to design their business model. These create boundaries of a cognitive nature that entrepreneurs must navigate. It has been suggested that sustainable entrepreneurship is inherently even more uncertain and complex than traditional entrepreneurship.
Martyna Jurek   +2 more
wiley   +1 more source

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