Results 201 to 210 of about 12,917 (271)

Aging‐Related Muscle Bmal1 Decline Contributes to Bone Loss in Mice via Enhancing IL‐1α–Mediated Osteoclastogenesis

open access: yesAging Cell, Volume 25, Issue 6, June 2026.
Aging‐related decline of muscle Bmal1 drives bone loss in mice by disrupting Hmox1 and increasing IL‐1α, which promotes osteoclast activity. Time‐restricted feeding reestablishes diurnal Hmox1 expression, reduces IL‐1α, and alleviates osteoporosis, offering a potential therapeutic strategy. ABSTRACT Osteoporosis, a common metabolic bone disorder linked
Kai Huang   +5 more
wiley   +1 more source

Hindlimb functional morphology and locomotor biomechanics of the small Late Triassic pseudosuchian reptile Gracilisuchus stipanicicorum (Archosauria: Gracilisuchidae)

open access: yesJournal of Anatomy, Volume 248, Issue 6, Page 1026-1063, June 2026.
A three‐dimensional biomechanical model of the musculoskeletal system is used to analyse the potential locomotor functions of the small (~1 kg) Late Triassic archosaurian reptile Gracilisuchus stipanicicorum. The study finds that, potentially like the ancestral archosaur, this taxon was probably quadrupedal, plantigrade and neither strongly sprawling ...
Agustina Lecuona   +3 more
wiley   +1 more source

Impact of Sarcopenia and Pretreatment Skeletal Muscle Loss on Survival in Endometrial Cancer Patients Treated With Immune Checkpoint Inhibitors

open access: yesJournal of Obstetrics and Gynaecology Research, Volume 52, Issue 6, June 2026.
ABSTRACT Aim Sarcopenia and cancer‐related muscle wasting may affect the efficacy of immune checkpoint inhibitors (ICIs). However, their prognostic significance in endometrial cancer (EC), particularly concerning skeletal muscle status at ICI initiation and pretreatment muscle change, remains unclear.
Komei Katayama   +9 more
wiley   +1 more source

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