Results 51 to 60 of about 22,717 (210)

Palmitoyl Acyltransferase Zdhhc17 Promotes Functional Recovery After Spinal Cord Injury by Targeting the Nuclear Transport Factors Kpna2 and Ipo9

Advanced Science, EarlyView.
In this study, we demonstrate that Zdhhc17, acting as a PAT, suppresses neuronal apoptosis and promotes axon regeneration after injury, thereby enhancing functional recovery following SCI. In this context, Kpna2 and Ipo9 serve as novel palmitoylation substrates of Zdhhc17, whose palmitoylation prevents the injury‐induced degradation of their proteins ...
Meixuan Chen, Huan Chen, Sining Ding, Fan Liu, Xiaofei Zheng, Yuan Wang, Ruitu Tian, Huan Li, Peilin Liu, Le Hu, Bin Liu, Limin Rong, Mangmang Li   +12 more
wiley   +1 more source

Assessment of the association between C2 vertebral morphology and facial asymmetry using CBCT and panoramic radiography

BMC Medical Imaging
Purpose To investigate the relationship between the morphology of the Axis (C2 vertebra) and facial asymmetry using cone-beam computed tomography (CBCT) and panoramic radiographs. Materials and methods A retrospective evaluation was performed on CBCT and
Çağan Erkman Şaylan, Mehmet Birol Özel, Alican Kuran, Enver Alper Sinanoğlu   +3 more
doaj   +1 more source

EXPERIMENTAL STUDY OF STABILITY AT CEMENT AND CEMENTLESS IMPLANTATION OF TRANSPEDICULAR SCREWS INTO VERTEBRAE WITH LOW MINERAL DENSITY OF BONE

Travmatologiâ i Ortopediâ Rossii, 2016
The stability of cemented and noncemented transpedicular screw implantations in vertebra with low mineral bone density was studied in experiment. We analyzed the destabilization of screw under distraction load, attached along longitudal axis of the screw
A. A. Afaunov, V. D. Usikov, D. A. Ptashnikov, K. K. Takhmazyan, M. Yu. Dokish   +4 more
doaj   +1 more source

Acid‐Responsive Nanobot‐Integrated Core‐Shell Microneedles Reprogram the Degenerative Annulus Fibrosus Microenvironment Through Epigenetic Suppression of Ferroptosis

Advanced Science, EarlyView.
An acid‐responsive core‐shell microneedle system normalizes the degenerative annulus fibrosus microenvironment by consuming pathological H+, generating O2, and providing NIR‐amplified redox buffering. Mechanistically, it epigenetically suppresses ferroptosis via DNMT3A‐dependent methylation of the ATF3 promoter, relieving ATF3‐mediated repression of ...
Lu Tan, Yan Zheng, Yue Lan, Zhuo Cheng, Siya Wang, Changqing Li, Yanqiu Wang, Minghan Liu   +7 more
wiley   +1 more source

Effect of exercise therapy on displacement of the center of rotation of lumbar vertebrae in patients with non-specific chronic low back pain

The Journal of Qazvin University of Medical Sciences, 2015
Background: The center of rotation (COR) of the lumbar vertebrae is one of the important characteristics in evaluation of lumbar spine kinematics. Objective: The aim of this study was to investigate the effect of exercise therapy on displacement of the ...
Y. Javadian, M. Akbari, Gh. Talebi
doaj  

MORPHOMETRIC PARAMETERS OF THE AXIS RELATED TO INTRALAMINAR FIXATION

Coluna/Columna
Objective: To evaluate the morphometric parameters of the C2 (axis) lamina related to the intralaminar fixation technique and compare the dimensions between sexes.
VITOR ARAúJO GONçALVES, MATHEUS PIPPA DEFINO, GABRIEL MATTOS GOES, THIAGO DE OLIVEIRA DORIGãO, HELTON LUIZ APARECIDO DEFINO   +4 more
doaj   +1 more source

Structural features and diagnostics of axis maldevelopments, a differentiated choice of surgical tactics

Ukrainian Neurosurgical Journal, 2015
Purpose. To study X-ray anatomy of craniovertebral zone considering structural features of the second cervical vertebra for differential diagnosis of pathology and its variable anatomy in the clinical aspect.Materials and methods.
Eugene Pedachenko, Eugene Slynko, Tatyana Malysheva, Oleg Robak, Oksana Chernenko   +4 more
doaj   +1 more source

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin, Yongcheng Chen, Yihao Xie, Dongyang Hu, Longhui Gong, Zhihua Chen, Linjie Chen, Minhao Gao, Qizhu Chen, Morgan Jones, Hui Wang, Xiuling You, Kenny Yat Hong Kwan, Shoutao Weng, Taidong Lyu, Xiang Chen, Yuxiao Zhu, Yusheng Wang, Bin Li, Xiangyang Wang, Xiaofeng Jia, Kailiang Zhou, Ouqiang Wu, Aimin Wu   +23 more
wiley   +1 more source

Absent posterior element of axis vertebra with myelopathy treated with C2, C3, and C4 arthrodesis: A case report and review of literature. [PDF]

J Neurosci Rural Pract, 2022
Singh DK, Shankar D, Chand V, Yadav K.
europepmc   +1 more source

Versatile Microgel Platform for Intervertebral Disc Degeneration Therapy: Targeting Pericyte‐Mediated Fibrosis and Protecting Nucleus Pulposus Cells

Advanced Science, EarlyView.
The engineered MMS@TRP microgel enables targeted, acid‐responsive delivery of a miR‐21 inhibitor to pericytes. It effectively suppresses disc fibrosis by inhibiting TGF‐β signaling while protecting nucleus pulposus cells via sustained, antioxidant tannic acid release.
Fei Ma, Zhen Zhao, Chuan Guo, Yuheng Liu, Yu Wang, Dengbo Yao, Weiqiang Lan, Dejun Zhong, Chen Fan, Yao He, Mei Zhang, Qingquan Kong, Yunfeng Lin   +12 more
wiley   +1 more source