Results 21 to 30 of about 744 (146)

UBE3C Facilitates the ER-Associated and Peripheral Degradation of Misfolded CFTR [PDF]

Cells, 2023
The ubiquitin E3 ligase UBE3C promotes the proteasomal degradation of cytosolic proteins and endoplasmic reticulum (ER) membrane proteins. UBE3C is proposed to function downstream of the RNF185/MBRL ER-associated degradation (ERAD) branch, contributing ...
Yuka Kamada, Hazuki Tateishi, Uta Nakayamada, Daichi Hinata, Ayuka Iwasaki, Jingxin Zhu, Ryosuke Fukuda, Tsukasa Okiyoneda   +7 more
doaj   +2 more sources

Effectiveness of afatinib after long-term gefitinib treatment for EGFR L858R and S768I compound mutation-positive lung adenocarcinoma: A case report [PDF]

Respiratory Medicine Case Reports
Afatinib, a second-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), irreversibly inhibits the pan-human epidermal growth factor receptor (HER) family.
Ayuka Dai-Shinozaki, Jun Sakakibara-Konishi, Kanako C. Hatanaka, Kento Wakabayashi, Naofumi Shinagawa, Yoshihiro Matsuno, Yutaka Hatanaka, Satoshi Konno   +7 more
doaj   +2 more sources

Risk of dementia with hearing impairment and social isolation [PDF]

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION This study aimed to determine whether the concomitance of hearing impairment and isolation with lack of conversation, which is considered self‐evident but has not been investigated extensively, is associated with the occurrence of dementia ...
Kouki Tomida, Takahiro Shimoda, Chika Nakajima, Ayuka Kawakami, Hiroyuki Shimada   +4 more
doaj   +2 more sources

Russian-Kalmyk Negotiations and the Shert’ of 1677 [PDF]

Oriental Studies
Introduction. The article discusses circumstances behind the Russian-Kalmyk negotiations and Shert’ (‘oath/treaty of allegiance’) of 1677. Goals. The study seeks to introduce some newly discovered sources dealing with seventeenth-century Kalmyk-Russian ...
Vladimir T. Tepkeev
doaj   +3 more sources

Mechanisms of the Effects of Polyphenols on Diabetic Nephropathy [PDF]

Current Issues in Molecular Biology
Diabetic nephropathy is a major challenge in medicine. While a variety of mechanisms underlie the onset and progression of diabetic nephropathy, oxidative stress is critical because it promotes inflammation and creates a vicious cycle that induces ...
Masumi Kamiyama, Kotoe Iijima, Rema Okuzawa, Ruka Kawata, Airi Kimura, Yuki Shinohara, Ayana Shimada, Mika Yamanaka, Ayuka Youda, Tamami Iwamoto   +9 more
doaj   +2 more sources

Structural insights into heterohexameric assembly of epilepsy-related ligand–receptor complex LGI1–ADAM22 [PDF]

eLife
Leucine-rich glioma-inactivated 1 protein (LGI1) is a secreted neuronal protein consisting of the N-terminal leucine-rich repeat (LRR) and C-terminal epitempin-repeat (EPTP) domains.
Takayuki Yamaguchi, Kei Okatsu, Masato Kubota, Ayuka Mitsumori, Atsushi Yamagata, Yuko Fukata, Masaki Fukata, Mikihiro Shibata, Shuya Fukai   +8 more
doaj   +2 more sources

Physical frailty in relation to immunosenescence involving pDC function in the Japanese elderly: a cross-sectional survey study [PDF]

Immunity & Ageing
Background Physical frailty leads to a decline in both immune function and physical function, which can lead to a worsening of infections in the elderly; however, the mechanisms have not been fully elucidated.
Yoshihiko Sugihara, Yusuke Ushida, Yuko Fukushima, Hajime Nozawa, Ryohei Tsuji, Daisuke Fujiwara, Ayuka Kawakami, Kouki Tomida, Hiroyuki Shimada, Mitsuo Maruyama   +9 more
doaj   +2 more sources

International Survey of Medical Students Exposure to Relevant Global Surgery (ISOMERS): A Cross-Sectional Study. [PDF]

World J Surg, 2022
Abstract Background The principles of global surgery should be taught as a part of the core curriculum in medical schools. The need for medical students to be familiar with the topic is increasing in acceptance. There is, however, a paucity of data on how medical students are exposed to global surgery.
InciSioN Collaborative.
europepmc   +2 more sources

‘Nowadays Kalmyks Maintain Firm Peace with the Crimea ...’: Kalmyk-Crimean Relations in the Late Seventeenth Century

Монголоведение, 2023
Introduction. The article deals with a little-known — though noticeable — episode in the history of late seventeenth-century Kalmyk-Crimean relations. The period remains somewhat understudied, and there are still unpublished sources on the topic.
Vladimir T. Tepkeev
doaj   +1 more source

Graphophonic Features of Khan Ayuka’s Name: A Case Study of 17th–18th Century Kalmyk Official Letters

Oriental Studies, 2021
Introduction. This article discusses the graphemic and phonemic features, as well as the origin of the name of the famous Kalmyk Ayuka Khan (1642–1724).
Daria B. Gedeeva
doaj   +1 more source