Results 181 to 190 of about 12,730,863 (301)
Model‐informed drug development is increasingly used to support chimeric antigen receptor (CAR)‐T‐cell therapy programs. However, most population pharmacokinetic (PK) CAR‐T‐cell models available in literature are variations of an empirical piecewise‐linear model, which accurately describes the observed data but lacks a mechanistic foundation.
Anna M. Mc Laughlin +4 more
wiley +1 more source
Exploring the role of blinatumomab in pediatric B-lymphoblastic lymphoma (B-LLy). [PDF]
Devine KJ, Fries C, Wistinghausen B.
europepmc +1 more source
Abstract UKALL14 (NCT01085617) T‐cell arm was a phase 3, randomized‐controlled trial. Adults aged 25–65 years were randomized 1:1 at entry to receive standard of care (SOC) or SOC + nelarabine 1.5 g/m2 (Days 1, 3, and 5) to be administered following second induction. The primary end‐point was event‐free survival (EFS).
Clare J. Rowntree +14 more
wiley +1 more source
Diplopia and bilateral optic disc swelling as the initial presentation of B-lymphoblastic lymphoma: a case report. [PDF]
Chang CH, Wang YH, Ko BS, Wei YH.
europepmc +1 more source
ABSTRACT The standard for assessing and recording the extent of the tumour, a necessity for most malignancies, is the Tumour Node Metastases (TNM) classification. The Union for International Cancer Control (UICC) TNM committee has defined this since the early 1950s.
James D. Brierley +8 more
wiley +1 more source
Somatic Mitochondrial–Nuclear DNA Transfer in Lymphoproliferative Disorders
ABSTRACT Introduction Somatic mitochondrial–nuclear DNA transfer (SMNT) is a process by which mitochondrial DNA (mtDNA), of varying sizes, integrate into the nuclear genome and has been previously reported in solid tumours. Methods EuroClonality‐NGS DNA Capture sequencing data from 755 lymphoid malignancies and 59 lymphoid cell lines were analysed for ...
James Peter Stewart +9 more
wiley +1 more source
Triple-hit TdT-positive high-grade B-cell lymphoma mimicking B-lymphoblastic lymphoma and exhibiting immunophenotypic change at relapse. [PDF]
Saito A +7 more
europepmc +1 more source

