Results 81 to 90 of about 30,612,164 (294)

Evaluation of different mathematical models and different b-value ranges of diffusion-weighted imaging in peripheral zone prostate cancer detection using b-value up to 4500 s/mm2

PLoS ONE, 2017
Objectives To evaluate the diagnostic performance of different mathematical models and different b-value ranges of diffusion-weighted imaging (DWI) in peripheral zone prostate cancer (PZ PCa) detection.
Zhaoyan Feng, X. Min, D. Margolis, Caohui Duan, Yuping Chen, V. Sah, N. Chaudhary, Basen Li, Zan Ke, Peipei Zhang, Liang Wang   +10 more
semanticscholar   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Fracture behavior of sandstone with partial filling flaw under mixed-mode loading: Three-point bending tests and discrete element method

Journal of Rock Mechanics and Geotechnical Engineering
The fracture behavior of natural fracture in the geological reservoir subjected to filling property, affects the crack initiation and propagation under stress perturbation.
Dongdong Ma, Yu Wu, Xiao Ma, Xunjian Hu, Wenbao Dong, Decheng Li, Lingyu Li   +6 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Spatiotemporal Distribution of the Magnitude of Completeness and b-Values in Mainland China Based on a Fused Multi-Source Earthquake Catalog

Entropy
The b-value is a critical parameter for gauging seismic activity and is essential for seismic hazard assessment, monitoring stress evolution in focal zones, and forecasting major earthquakes. The minimum magnitude of completeness (Mc), a key indicator of
Chen Li, Ziyi Li, Mengqiao Duan, Lianqing Zhou   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

A comparative study of shear crack growth mechanisms in concrete through acoustic emission analysis

Scientific Reports
The shear failure of concrete is a sudden brittle failure, which is difficult to be forewarned. To investigate the shear crack mechanisms in concrete, this study first systematic compared acoustic emission (AE) behavior during direct shear tests ...
Lian Huang, Junjie Deng, Duo Hu, Xiaolong Li, Yun Liu, Weihua Zhu   +5 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

A review and new insights on the estimation of the b-valueand its uncertainty

Annals of Geophysics, 2003
The estimation of the b-value of the Gutenberg-Richter Law and its uncertainty is crucial in seismic hazard studies, as well as in verifying theoretical assertions, such as, for example, the universality of the Gutenberg-Richter Law.
L. Sandri, W. Marzocchi
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source