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Aflatoxin B1: metabolism, toxicology, and its involvement in oxidative stress and cancer development

Toxicology Mechanisms and Methods, 2021
Aflatoxins are a class of carcinogenic mycotoxins produced by Aspergillus fungi, which are widely distributed in nature. Aflatoxin B1 (AFB1) is the most toxic of these compounds and its metabolites have a variety of biological activities, including acute
W. Cao, Pan Yu, Kepeng Yang, Dongli Cao
semanticscholar   +1 more source

The roles of hnRNP A2/B1 in RNA biology and disease

Wiley Interdisciplinary Reviews - RNA, 2020
The RNA‐binding protein hnRNPA2/B1 is a member of the hnRNPs family and is widely expressed in various tissues. hnRNPA2/B1 recognizes and binds specific RNA substrates and DNA motifs and is involved in the transcription, splicing processing, transport ...
Yu Liu, Song-Lin Shi
semanticscholar   +1 more source

Abstract 5802: An orally available small molecule JMBI-001 elicits MYC-synthetic lethality and anti-tumor immunity by disabling MKLP2-mediated cellular processes

Cancer Research
The MYC oncogene, a pivotal regulator of various cellular processes, is deregulated in approximately 70 % of human malignancies. Mitotic Kinesin-like Protein 2 (MKLP2) plays a versatile role in both interphase and mitosis and has emerged as a ...
Ting Zhang   +15 more
semanticscholar   +1 more source

Favorable angiogenic properties of the borosilicate bioactive glass 0106-B1 result in enhanced in vivo osteoid formation compared to 45S5 Bioglass.

Biomaterials Science, 2019
The 45S5-bioactive glass (BG) composition is the most commonly investigated amongst BG-based bone substitutes. By changing BG compositions and by addition of therapeutically active ions such as boron, the biological features of BGs can be tailored ...
F. Westhauser   +6 more
semanticscholar   +1 more source

Abyssomicin Monomers and Dimers from the Marine-Derived Streptomyces koyangensis SCSIO 5802.

Journal of Natural Products, 2018
Three new abyssomicin monomers designated neoabyssomicins D (1), E (2), and A2 (3) and the two dimeric neoabyssomicins F (4) and G (5) were discovered from the marine-derived Streptomyces koyangensis SCSIO 5802, and their structures rigorously elucidated.
Hongbo Huang   +9 more
semanticscholar   +1 more source

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